148375

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1252975..1253452 Replicon chromosome
Accession NZ_CP047859
Organism Staphylococcus aureus strain UP_1405

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S65_RS06465 Protein ID WP_000052076.1
Coordinates 1253264..1253452 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S65_RS06460 Protein ID WP_001059690.1
Coordinates 1252975..1253235 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S65_RS06425 1248368..1249084 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
E3S65_RS06430 1249232..1249654 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
E3S65_RS06435 1250053..1250547 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S65_RS06440 1250702..1251319 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
E3S65_RS06445 1251392..1251973 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
E3S65_RS06450 1252198..1252434 + 237 WP_000349581.1 hypothetical protein -
E3S65_RS06455 1252431..1252634 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S65_RS06460 1252975..1253235 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S65_RS06465 1253264..1253452 + 189 WP_000052076.1 hypothetical protein Toxin
E3S65_RS06470 1253640..1254209 + 570 WP_001106658.1 hypothetical protein -
E3S65_RS06475 1254297..1254581 + 285 WP_001004399.1 hypothetical protein -
E3S65_RS06480 1254643..1254861 + 219 WP_000005886.1 hypothetical protein -
E3S65_RS06485 1255353..1255553 - 201 WP_001059082.1 cold-shock protein -
E3S65_RS06490 1255910..1256596 - 687 WP_000141557.1 thermonuclease family protein -
E3S65_RS06495 1256937..1257458 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T148375 WP_000052076.1 NZ_CP047859:1253264-1253452 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148375 NZ_CP063503:c4266087-4265773 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148375 WP_001059690.1 NZ_CP047859:1252975-1253235 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148375 NZ_CP063503:c4265776-4265360 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References