Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1207715..1208192 Replicon chromosome
Accession NZ_CP047856
Organism Staphylococcus aureus strain UP_1435

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S66_RS06155 Protein ID WP_000052076.1
Coordinates 1208004..1208192 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S66_RS06150 Protein ID WP_001059690.1
Coordinates 1207715..1207975 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S66_RS06115 1203108..1203824 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
E3S66_RS06120 1203972..1204394 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
E3S66_RS06125 1204793..1205287 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S66_RS06130 1205442..1206059 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
E3S66_RS06135 1206132..1206713 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
E3S66_RS06140 1206938..1207174 + 237 WP_000349581.1 hypothetical protein -
E3S66_RS06145 1207171..1207374 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S66_RS06150 1207715..1207975 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S66_RS06155 1208004..1208192 + 189 WP_000052076.1 hypothetical protein Toxin
E3S66_RS06160 1208380..1208949 + 570 WP_001106658.1 hypothetical protein -
E3S66_RS06165 1209037..1209321 + 285 WP_001004399.1 hypothetical protein -
E3S66_RS06170 1209383..1209601 + 219 WP_000005886.1 hypothetical protein -
E3S66_RS06175 1210093..1210293 - 201 WP_001059082.1 cold-shock protein -
E3S66_RS06180 1210650..1211336 - 687 WP_000141557.1 thermonuclease family protein -
E3S66_RS06185 1211677..1212198 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 1133649..1225983 92334


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T148354 WP_000052076.1 NZ_CP047856:1208004-1208192 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148354 NZ_CP063499:4481663-4481998 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148354 WP_001059690.1 NZ_CP047856:1207715-1207975 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148354 NZ_CP063499:4481415-4481663 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGATCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References