Detailed information of TA system TA148336

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1208757..1209234
• Replicon: chromosome
• Accession: NZ_CP047854
• Organism: Staphylococcus aureus strain UP_1525

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: E3S68_RS06140
• Protein ID: WP_000052076.1
• Coordinates: 1209046..1209234 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: E3S68_RS06135
• Protein ID: WP_160199178.1
• Coordinates: 1208757..1209017 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S68_RS06100	1204150..1204866	-	717	WP_000150011.1	type I 3-dehydroquinate dehydratase	-
E3S68_RS06105	1205014..1205436	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
E3S68_RS06110	1205835..1206329	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
E3S68_RS06115	1206484..1207101	+	618	WP_000255551.1	LysE/ArgO family amino acid transporter	-
E3S68_RS06120	1207174..1207755	-	582	WP_001140693.1	phosphoglycerate mutase family protein	-
E3S68_RS06125	1207980..1208216	+	237	WP_000349581.1	hypothetical protein	-
E3S68_RS06130	1208213..1208416	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
E3S68_RS06135	1208757..1209017	+	261	WP_160199178.1	hypothetical protein	Antitoxin
E3S68_RS06140	1209046..1209234	+	189	WP_000052076.1	hypothetical protein	Toxin
E3S68_RS06145	1209422..1209991	+	570	WP_001106658.1	hypothetical protein	-
E3S68_RS06150	1210079..1210363	+	285	WP_001004399.1	hypothetical protein	-
E3S68_RS06155	1210425..1210643	+	219	WP_000005886.1	hypothetical protein	-
E3S68_RS06160	1211135..1211335	-	201	WP_001059082.1	cold-shock protein	-
E3S68_RS06165	1211692..1212378	-	687	WP_000141557.1	thermonuclease family protein	-
E3S68_RS06170	1212719..1213240	-	522	WP_000824482.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T148336 WP_000052076.1 NZ_CP047854:1209046-1209234 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T148336 NZ_CP063496:c53169-52888 [Escherichia coli]
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9974.11 Da
• Isoelectric Point: 4.0624

>AT148336 WP_160199178.1 NZ_CP047854:1208757-1209017 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWFLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT148336 NZ_CP063496:c53410-53159 [Escherichia coli]
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18