Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1167133..1167610 Replicon chromosome
Accession NZ_CP047852
Organism Staphylococcus aureus strain UP_274

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S71_RS05865 Protein ID WP_000052076.1
Coordinates 1167422..1167610 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S71_RS05860 Protein ID WP_001059690.1
Coordinates 1167133..1167393 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S71_RS05825 1162526..1163242 - 717 WP_000150018.1 type I 3-dehydroquinate dehydratase -
E3S71_RS05830 1163390..1163812 + 423 WP_000974455.1 organic hydroperoxide resistance protein -
E3S71_RS05835 1164211..1164705 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S71_RS05840 1164860..1165477 + 618 WP_160199889.1 LysE/ArgO family amino acid transporter -
E3S71_RS05845 1165550..1166131 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
E3S71_RS05850 1166356..1166592 + 237 WP_000368687.1 hypothetical protein -
E3S71_RS05855 1166589..1166792 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S71_RS05860 1167133..1167393 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S71_RS05865 1167422..1167610 + 189 WP_000052076.1 hypothetical protein Toxin
E3S71_RS05870 1167798..1168367 + 570 WP_001106655.1 hypothetical protein -
E3S71_RS05875 1168455..1168739 + 285 WP_001004399.1 hypothetical protein -
E3S71_RS05880 1168801..1169019 + 219 WP_000005884.1 hypothetical protein -
E3S71_RS05885 1169514..1169714 - 201 WP_001059082.1 cold-shock protein -
E3S71_RS05890 1170071..1170757 - 687 WP_000141557.1 thermonuclease family protein -
E3S71_RS05895 1171098..1171619 - 522 WP_000824484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T148319 WP_000052076.1 NZ_CP047852:1167422-1167610 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148319 NZ_CP063492:c3575365-3575262 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148319 WP_001059690.1 NZ_CP047852:1167133-1167393 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148319 NZ_CP063492:3575224-3575495 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References