Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2159983..2160497 Replicon chromosome
Accession NZ_CP047851
Organism Staphylococcus aureus strain UP_338

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag E3S74_RS10535 Protein ID WP_000581791.1
Coordinates 2159983..2160192 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag E3S74_RS10540 Protein ID WP_000138934.1
Coordinates 2160204..2160497 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S74_RS10515 2155872..2156942 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
E3S74_RS10520 2157260..2158462 + 1203 WP_001109939.1 rod shape-determining protein RodA -
E3S74_RS10525 2158623..2159306 - 684 Protein_2036 transposase -
E3S74_RS10530 2159718..2159855 - 138 WP_000828354.1 hypothetical protein -
E3S74_RS10535 2159983..2160192 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
E3S74_RS10540 2160204..2160497 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3S74_RS10545 2160663..2162147 + 1485 WP_000571560.1 cardiolipin synthase -
E3S74_RS10550 2162175..2162822 + 648 WP_001187612.1 HD domain-containing protein -
E3S74_RS10560 2162979..2163278 + 300 WP_001793952.1 hypothetical protein -
E3S74_RS10565 2163435..2164307 - 873 WP_000725802.1 membrane protein insertase YidC -
E3S74_RS10570 2164393..2165034 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T148307 WP_000581791.1 NZ_CP047851:c2160192-2159983 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T148307 NZ_CP063492:c1311291-1311034 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT148307 WP_000138934.1 NZ_CP047851:c2160497-2160204 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT148307 NZ_CP063492:c1311022-1310477 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References