Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1592752..1593540 Replicon chromosome
Accession NZ_CP047851
Organism Staphylococcus aureus strain UP_338

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag E3S74_RS07600 Protein ID WP_000525004.1
Coordinates 1593079..1593540 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag E3S74_RS07595 Protein ID WP_000333630.1
Coordinates 1592752..1593066 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S74_RS07545 1588292..1589458 - 1167 WP_031834538.1 DUF2800 domain-containing protein -
E3S74_RS07550 1589455..1589817 - 363 WP_000985976.1 hypothetical protein -
E3S74_RS07555 1589832..1590155 - 324 WP_000174994.1 hypothetical protein -
E3S74_RS07560 1590234..1590395 - 162 WP_001285954.1 DUF1270 domain-containing protein -
E3S74_RS07565 1590408..1590671 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
E3S74_RS07570 1590696..1590911 - 216 WP_001097552.1 hypothetical protein -
E3S74_RS07575 1590966..1591331 + 366 WP_001128433.1 hypothetical protein -
E3S74_RS07580 1591300..1591545 - 246 WP_001025401.1 DUF2829 domain-containing protein -
E3S74_RS07585 1591574..1592350 - 777 WP_001148544.1 Rha family transcriptional regulator -
E3S74_RS07590 1592364..1592600 - 237 WP_001121027.1 helix-turn-helix domain-containing protein -
E3S74_RS07595 1592752..1593066 + 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
E3S74_RS07600 1593079..1593540 + 462 WP_000525004.1 hypothetical protein Toxin
E3S74_RS07605 1593558..1594142 + 585 WP_000825948.1 hypothetical protein -
E3S74_RS07610 1594481..1595104 - 624 WP_001166482.1 hypothetical protein -
E3S74_RS07615 1595214..1596419 + 1206 WP_000264191.1 site-specific integrase -
E3S74_RS07620 1596462..1598504 - 2043 WP_001794062.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1551826..1614069 62243


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T148302 WP_000525004.1 NZ_CP047851:1593079-1593540 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T148302 NZ_CP063489:17723-17971 [Escherichia coli]
ATGGGGAAAACAGATAAGCTACTGGCAAAGTTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTGGTCGTTTTGTT
TTCCTCTTTGGGATATGTCAAAAAGGAAATGCAGGGGTCAAGAGTGCGGTTTTTCAATGCTGAAATCAATCACACCATAT
TAATGCATCGTCCACATCCGGAAAGTTATATCAAAGGTGGTACGCTGAAAGCAATTAAACAGAATCTGAAAGAGGCTGGA
TTATTATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT148302 WP_000333630.1 NZ_CP047851:1592752-1593066 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT148302 NZ_CP063489:17968-18315 [Escherichia coli]
ATGAAACATTTAAAATATAAAGGATATTTAGGCACGGTTGAACCCGATTTTGAAAATAATGTCCTGTATGGAAAACTGGC
GTTTATTCGGGACCTGGTAACTTATGAGGCTTCTACATTAGCTGAACTGGAACAGGAGTTTAAAACATCTGTTGATCTGT
ATTTACAGTCTTGTGTGGAGGATGGAAAGGAACCTGATACCCCGTTTAAAGGCGTGTTTAACGTCAGGCTTGATCCAGAA
CTGCATCGTCGGGTAGCAGAAATGGCGATGGAAGAAGATTTATCGTTGAATGCCTTTGTTAATAAGGCTCTGGAAAAAGA
AGTCAGCAATCATCGCGCAGGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References