Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 862984..863461 Replicon chromosome
Accession NZ_CP047851
Organism Staphylococcus aureus strain UP_338

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S74_RS04085 Protein ID WP_000052076.1
Coordinates 862984..863172 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S74_RS04090 Protein ID WP_001059690.1
Coordinates 863201..863461 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S74_RS04055 858937..859494 + 558 WP_000824491.1 hypothetical protein -
E3S74_RS04060 859835..860521 + 687 WP_001574556.1 thermonuclease family protein -
E3S74_RS04065 860878..861078 + 201 WP_001059082.1 cold-shock protein -
E3S74_RS04070 861575..861793 - 219 WP_000005879.1 hypothetical protein -
E3S74_RS04075 861855..862139 - 285 WP_001004401.1 hypothetical protein -
E3S74_RS04080 862227..862796 - 570 WP_107375201.1 hypothetical protein -
E3S74_RS04085 862984..863172 - 189 WP_000052076.1 hypothetical protein Toxin
E3S74_RS04090 863201..863461 - 261 WP_001059690.1 hypothetical protein Antitoxin
E3S74_RS04095 863802..864005 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S74_RS04100 864002..864238 - 237 WP_000368687.1 hypothetical protein -
E3S74_RS04105 864463..865044 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3S74_RS04110 865117..865734 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
E3S74_RS04115 865890..866384 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S74_RS04120 866783..867205 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
E3S74_RS04125 867353..868069 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T148297 WP_000052076.1 NZ_CP047851:c863172-862984 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148297 NZ_CP063487:4464172-4464279 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148297 WP_001059690.1 NZ_CP047851:c863461-863201 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148297 NZ_CP063487:c4464125-4464059 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References