Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2654779..2655293 Replicon chromosome
Accession NZ_CP047849
Organism Staphylococcus aureus strain UP_403

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag E3S76_RS13090 Protein ID WP_000581792.1
Coordinates 2655084..2655293 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag E3S76_RS13085 Protein ID WP_000138932.1
Coordinates 2654779..2655072 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S76_RS13055 2650042..2650683 + 642 WP_000483153.1 thiamine phosphate synthase -
E3S76_RS13060 2650769..2651641 + 873 WP_000725802.1 membrane protein insertase YidC -
E3S76_RS13075 2652454..2653101 - 648 WP_001187629.1 HD domain-containing protein -
E3S76_RS13080 2653129..2654613 - 1485 WP_000571549.1 cardiolipin synthase -
E3S76_RS13085 2654779..2655072 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3S76_RS13090 2655084..2655293 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
E3S76_RS13095 2655421..2655558 + 138 WP_000828354.1 hypothetical protein -
E3S76_RS13100 2655822..2657024 - 1203 WP_001109939.1 rod shape-determining protein RodA -
E3S76_RS13105 2657342..2658412 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
E3S76_RS13110 2658427..2659785 + 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T148295 WP_000581792.1 NZ_CP047849:2655084-2655293 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T148295 NZ_CP063487:c4204035-4203859 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT148295 WP_000138932.1 NZ_CP047849:2654779-2655072 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT148295 NZ_CP063487:c4203813-4203397 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References