Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1172473..1172950 Replicon chromosome
Accession NZ_CP047849
Organism Staphylococcus aureus strain UP_403

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag E3S76_RS05830 Protein ID WP_000052078.1
Coordinates 1172762..1172950 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S76_RS05825 Protein ID WP_001059690.1
Coordinates 1172473..1172733 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S76_RS05790 1167866..1168582 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
E3S76_RS05795 1168730..1169152 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
E3S76_RS05800 1169551..1170045 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S76_RS05805 1170200..1170817 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
E3S76_RS05810 1170890..1171471 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
E3S76_RS05815 1171696..1171932 + 237 WP_000368687.1 hypothetical protein -
E3S76_RS05820 1171929..1172132 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S76_RS05825 1172473..1172733 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S76_RS05830 1172762..1172950 + 189 WP_000052078.1 hypothetical protein Toxin
E3S76_RS05835 1173138..1173707 + 570 WP_001106654.1 hypothetical protein -
E3S76_RS05840 1173795..1174079 + 285 WP_001004395.1 hypothetical protein -
E3S76_RS05845 1174141..1174359 + 219 WP_000005886.1 hypothetical protein -
E3S76_RS05850 1174856..1175056 - 201 WP_001059082.1 cold-shock protein -
E3S76_RS05855 1175413..1176099 - 687 WP_001548082.1 thermonuclease family protein -
E3S76_RS05860 1176440..1176910 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T148286 WP_000052078.1 NZ_CP047849:1172762-1172950 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148286 NZ_CP063487:2041936-2042043 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGTGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148286 WP_001059690.1 NZ_CP047849:1172473-1172733 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148286 NZ_CP063487:c2041888-2041822 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References