Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2672075..2672589 Replicon chromosome
Accession NZ_CP047847
Organism Staphylococcus aureus strain UP_522

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag E3S80_RS13390 Protein ID WP_000581793.1
Coordinates 2672380..2672589 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag E3S80_RS13385 Protein ID WP_000138932.1
Coordinates 2672075..2672368 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S80_RS13360 2667537..2668178 + 642 WP_000483155.1 thiamine phosphate synthase -
E3S80_RS13365 2668264..2669136 + 873 WP_000725802.1 membrane protein insertase YidC -
E3S80_RS13375 2669750..2670397 - 648 WP_031590210.1 HD domain-containing protein -
E3S80_RS13380 2670425..2671909 - 1485 WP_000571549.1 cardiolipin synthase -
E3S80_RS13385 2672075..2672368 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3S80_RS13390 2672380..2672589 + 210 WP_000581793.1 heavy-metal-associated domain-containing protein Toxin
E3S80_RS13395 2672717..2672854 + 138 WP_000828354.1 hypothetical protein -
E3S80_RS13400 2673117..2674319 - 1203 WP_031590208.1 rod shape-determining protein RodA -
E3S80_RS13405 2674637..2675707 + 1071 WP_000159627.1 D-alanine--D-alanine ligase -
E3S80_RS13410 2675722..2677080 + 1359 WP_000611482.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T148278 WP_000581793.1 NZ_CP047847:2672380-2672589 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T148278 NZ_CP063486:15403-15684 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT148278 WP_000138932.1 NZ_CP047847:2672075-2672368 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT148278 NZ_CP063486:15137-15406 [Escherichia coli]
ATGGCACAGATTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGCCTCTCAGTTAATCCGGGATTTTATGCGCCAGACTGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCCGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References