148269

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1223913..1224390 Replicon chromosome
Accession NZ_CP047847
Organism Staphylococcus aureus strain UP_522

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S80_RS06340 Protein ID WP_000052076.1
Coordinates 1224202..1224390 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S80_RS06335 Protein ID WP_001059690.1
Coordinates 1223913..1224173 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S80_RS06300 1219305..1220021 - 717 WP_000150016.1 type I 3-dehydroquinate dehydratase -
E3S80_RS06305 1220169..1220591 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
E3S80_RS06310 1220990..1221484 + 495 WP_160199379.1 GNAT family N-acetyltransferase -
E3S80_RS06315 1221640..1222257 + 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
E3S80_RS06320 1222330..1222911 - 582 WP_001140697.1 phosphoglycerate mutase family protein -
E3S80_RS06325 1223136..1223372 + 237 WP_000368687.1 hypothetical protein -
E3S80_RS06330 1223369..1223572 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S80_RS06335 1223913..1224173 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S80_RS06340 1224202..1224390 + 189 WP_000052076.1 hypothetical protein Toxin
E3S80_RS06345 1224578..1225147 + 570 WP_001106652.1 hypothetical protein -
E3S80_RS06350 1225235..1225519 + 285 WP_001004401.1 hypothetical protein -
E3S80_RS06355 1225581..1225799 + 219 WP_000005887.1 hypothetical protein -
E3S80_RS06360 1226295..1226495 - 201 WP_001059082.1 cold-shock protein -
E3S80_RS06365 1226852..1227538 - 687 WP_001641381.1 thermonuclease family protein -
E3S80_RS06370 1227879..1228355 - 477 WP_000824477.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T148269 WP_000052076.1 NZ_CP047847:1224202-1224390 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148269 NZ_CP063483:c3176164-3175988 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148269 WP_001059690.1 NZ_CP047847:1223913-1224173 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148269 NZ_CP063483:c3175942-3175526 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References