Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1139123..1139600 Replicon chromosome
Accession NZ_CP047845
Organism Staphylococcus aureus strain UP_591

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S82_RS05665 Protein ID WP_000052076.1
Coordinates 1139412..1139600 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S82_RS05660 Protein ID WP_001059690.1
Coordinates 1139123..1139383 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S82_RS05625 1134517..1135233 - 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -
E3S82_RS05630 1135381..1135803 + 423 WP_000974451.1 organic hydroperoxide resistance protein -
E3S82_RS05635 1136201..1136695 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S82_RS05640 1136851..1137468 + 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
E3S82_RS05645 1137541..1138122 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3S82_RS05650 1138346..1138582 + 237 WP_000368687.1 hypothetical protein -
E3S82_RS05655 1138579..1138782 - 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
E3S82_RS05660 1139123..1139383 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S82_RS05665 1139412..1139600 + 189 WP_000052076.1 hypothetical protein Toxin
E3S82_RS05670 1139788..1140357 + 570 WP_001106662.1 hypothetical protein -
E3S82_RS05675 1140445..1140717 + 273 WP_001004400.1 hypothetical protein -
E3S82_RS05680 1140790..1141008 + 219 WP_000005884.1 hypothetical protein -
E3S82_RS05685 1141505..1141705 - 201 WP_001059082.1 cold-shock protein -
E3S82_RS05690 1142062..1142748 - 687 WP_001622483.1 thermonuclease family protein -
E3S82_RS05695 1143089..1143610 - 522 WP_000824479.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp / sell / sec / hlb / groEL 1135381..1184661 49280


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T148257 WP_000052076.1 NZ_CP047845:1139412-1139600 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148257 NZ_CP063483:917376-917483 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148257 WP_001059690.1 NZ_CP047845:1139123-1139383 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148257 NZ_CP063483:c917328-917262 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References