Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsdAT/- |
| Location | 2126639..2127153 | Replicon | chromosome |
| Accession | NZ_CP047843 | ||
| Organism | Staphylococcus aureus strain UP_620 | ||
Toxin (Protein)
| Gene name | TsdT | Uniprot ID | T1YA99 |
| Locus tag | E3S83_RS10560 | Protein ID | WP_000581792.1 |
| Coordinates | 2126639..2126848 (-) | Length | 70 a.a. |
Antitoxin (Protein)
| Gene name | TsdA | Uniprot ID | W8UW13 |
| Locus tag | E3S83_RS10565 | Protein ID | WP_000138932.1 |
| Coordinates | 2126860..2127153 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3S83_RS10540 | 2122147..2123505 | - | 1359 | WP_000611465.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| E3S83_RS10545 | 2123520..2124590 | - | 1071 | WP_000159631.1 | D-alanine--D-alanine ligase | - |
| E3S83_RS10550 | 2124908..2126110 | + | 1203 | WP_001109939.1 | rod shape-determining protein RodA | - |
| E3S83_RS10555 | 2126374..2126511 | - | 138 | WP_000828354.1 | hypothetical protein | - |
| E3S83_RS10560 | 2126639..2126848 | - | 210 | WP_000581792.1 | heavy-metal-associated domain-containing protein | Toxin |
| E3S83_RS10565 | 2126860..2127153 | - | 294 | WP_000138932.1 | copper-sensing transcriptional repressor CsoR | Antitoxin |
| E3S83_RS10570 | 2127319..2128803 | + | 1485 | WP_000571549.1 | cardiolipin synthase | - |
| E3S83_RS10575 | 2128831..2129478 | + | 648 | WP_001187634.1 | HD domain-containing protein | - |
| E3S83_RS10585 | 2130205..2131077 | - | 873 | WP_000725802.1 | membrane protein insertase YidC | - |
| E3S83_RS10590 | 2131163..2131804 | - | 642 | WP_000483153.1 | thiamine phosphate synthase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 70 a.a. Molecular weight: 7843.77 Da Isoelectric Point: 4.1008
>T148245 WP_000581792.1 NZ_CP047843:c2126848-2126639 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF
Download Length: 210 bp
>T148245 NZ_CP063479:c3341801-3341698 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 98 a.a. Molecular weight: 11197.82 Da Isoelectric Point: 6.2243
>AT148245 WP_000138932.1 NZ_CP047843:c2127153-2126860 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD
Download Length: 294 bp
>AT148245 NZ_CP063479:3341660-3341931 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|