Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 814499..814976 | Replicon | chromosome |
| Accession | NZ_CP047843 | ||
| Organism | Staphylococcus aureus strain UP_620 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | E3S83_RS03875 | Protein ID | WP_000052076.1 |
| Coordinates | 814499..814687 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | E3S83_RS03880 | Protein ID | WP_001059690.1 |
| Coordinates | 814716..814976 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3S83_RS03845 | 810540..811010 | + | 471 | WP_000824467.1 | hypothetical protein | - |
| E3S83_RS03850 | 811351..812037 | + | 687 | WP_001641381.1 | thermonuclease family protein | - |
| E3S83_RS03855 | 812394..812594 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| E3S83_RS03860 | 813090..813308 | - | 219 | WP_000005886.1 | hypothetical protein | - |
| E3S83_RS03865 | 813370..813654 | - | 285 | WP_001004401.1 | hypothetical protein | - |
| E3S83_RS03870 | 813742..814311 | - | 570 | WP_001106654.1 | hypothetical protein | - |
| E3S83_RS03875 | 814499..814687 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| E3S83_RS03880 | 814716..814976 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| E3S83_RS03885 | 815317..815520 | + | 204 | WP_000145164.1 | sterile alpha motif-like domain-containing protein | - |
| E3S83_RS03890 | 815517..815753 | - | 237 | WP_000368687.1 | hypothetical protein | - |
| E3S83_RS03895 | 815978..816559 | + | 582 | WP_001140693.1 | phosphoglycerate mutase family protein | - |
| E3S83_RS03900 | 816632..817249 | - | 618 | WP_000255557.1 | LysE/ArgO family amino acid transporter | - |
| E3S83_RS03905 | 817337..818983 | - | 1647 | WP_000277718.1 | IS1182 family transposase | - |
| E3S83_RS03910 | 819323..819817 | - | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 817337..818983 | 1646 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T148242 WP_000052076.1 NZ_CP047843:c814687-814499 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T148242 NZ_CP063479:c2673246-2673139 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT148242 WP_001059690.1 NZ_CP047843:c814976-814716 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT148242 NZ_CP063479:2673293-2673359 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |