148241

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2649046..2649575 Replicon chromosome
Accession NZ_CP047841
Organism Staphylococcus aureus strain UP_644

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E3S84_RS13140 Protein ID WP_000621175.1
Coordinates 2649213..2649575 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag E3S84_RS13135 Protein ID WP_000948331.1
Coordinates 2649046..2649216 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S84_RS13105 2644082..2644642 + 561 WP_001092410.1 K(+)-transporting ATPase subunit C -
E3S84_RS13110 2644851..2645330 + 480 WP_031590204.1 hypothetical protein -
E3S84_RS13115 2645323..2646906 + 1584 WP_001294626.1 PH domain-containing protein -
E3S84_RS13120 2646893..2647384 + 492 WP_072353916.1 PH domain-containing protein -
E3S84_RS13125 2647388..2647747 + 360 WP_000581197.1 holo-ACP synthase -
E3S84_RS13130 2647813..2648961 + 1149 WP_001281154.1 alanine racemase -
E3S84_RS13135 2649046..2649216 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
E3S84_RS13140 2649213..2649575 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E3S84_RS13145 2649925..2650926 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
E3S84_RS13150 2651045..2651371 + 327 WP_001052491.1 anti-sigma factor antagonist -
E3S84_RS13155 2651373..2651852 + 480 WP_001190829.1 anti-sigma B factor RsbW -
E3S84_RS13160 2651827..2652597 + 771 WP_001041102.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T148241 WP_000621175.1 NZ_CP047841:2649213-2649575 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T148241 NZ_CP063479:c2672710-2672603 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT148241 WP_000948331.1 NZ_CP047841:2649046-2649216 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT148241 NZ_CP063479:2672763-2672824 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References