Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2629321..2629835 Replicon chromosome
Accession NZ_CP047841
Organism Staphylococcus aureus strain UP_644

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag E3S84_RS13050 Protein ID WP_000581793.1
Coordinates 2629626..2629835 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag E3S84_RS13045 Protein ID WP_000138932.1
Coordinates 2629321..2629614 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S84_RS13020 2624783..2625424 + 642 WP_000483155.1 thiamine phosphate synthase -
E3S84_RS13025 2625510..2626382 + 873 WP_000725802.1 membrane protein insertase YidC -
E3S84_RS13035 2626996..2627643 - 648 WP_031590210.1 HD domain-containing protein -
E3S84_RS13040 2627671..2629155 - 1485 WP_000571549.1 cardiolipin synthase -
E3S84_RS13045 2629321..2629614 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3S84_RS13050 2629626..2629835 + 210 WP_000581793.1 heavy-metal-associated domain-containing protein Toxin
E3S84_RS13055 2629963..2630100 + 138 WP_000828354.1 hypothetical protein -
E3S84_RS13060 2630363..2631565 - 1203 WP_031590208.1 rod shape-determining protein RodA -
E3S84_RS13065 2631883..2632953 + 1071 WP_000159627.1 D-alanine--D-alanine ligase -
E3S84_RS13070 2632968..2634326 + 1359 WP_000611482.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T148240 WP_000581793.1 NZ_CP047841:2629626-2629835 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T148240 NZ_CP063479:c2672175-2672068 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT148240 WP_000138932.1 NZ_CP047841:2629321-2629614 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT148240 NZ_CP063479:2672223-2672289 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References