Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1166383..1166860 Replicon chromosome
Accession NZ_CP047841
Organism Staphylococcus aureus strain UP_644

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S84_RS05905 Protein ID WP_000052076.1
Coordinates 1166672..1166860 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S84_RS05900 Protein ID WP_001059690.1
Coordinates 1166383..1166643 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S84_RS05865 1161775..1162491 - 717 WP_000150016.1 type I 3-dehydroquinate dehydratase -
E3S84_RS05870 1162639..1163061 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
E3S84_RS05875 1163460..1163954 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S84_RS05880 1164110..1164727 + 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
E3S84_RS05885 1164800..1165381 - 582 WP_001140697.1 phosphoglycerate mutase family protein -
E3S84_RS05890 1165606..1165842 + 237 WP_000368687.1 hypothetical protein -
E3S84_RS05895 1165839..1166042 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S84_RS05900 1166383..1166643 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S84_RS05905 1166672..1166860 + 189 WP_000052076.1 hypothetical protein Toxin
E3S84_RS05910 1167048..1167617 + 570 WP_001106652.1 hypothetical protein -
E3S84_RS05915 1167705..1167989 + 285 WP_001004401.1 hypothetical protein -
E3S84_RS05920 1168051..1168269 + 219 WP_000005887.1 hypothetical protein -
E3S84_RS05925 1168765..1168965 - 201 WP_001059082.1 cold-shock protein -
E3S84_RS05930 1169322..1170008 - 687 WP_001641381.1 thermonuclease family protein -
E3S84_RS05935 1170349..1170825 - 477 WP_000824477.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T148231 WP_000052076.1 NZ_CP047841:1166672-1166860 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148231 NZ_CP063479:c184120-183845 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATAGTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148231 WP_001059690.1 NZ_CP047841:1166383-1166643 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148231 NZ_CP063479:c183848-183489 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References