Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2721474..2722003 Replicon chromosome
Accession NZ_CP047839
Organism Staphylococcus aureus strain UP_678

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag E3S85_RS13355 Protein ID WP_000621176.1
Coordinates 2721641..2722003 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag E3S85_RS13350 Protein ID WP_000948331.1
Coordinates 2721474..2721644 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S85_RS13320 2716510..2717070 + 561 WP_001092414.1 K(+)-transporting ATPase subunit C -
E3S85_RS13325 2717279..2717758 + 480 WP_001287082.1 hypothetical protein -
E3S85_RS13330 2717751..2719328 + 1578 WP_160176116.1 PH domain-containing protein -
E3S85_RS13335 2719321..2719812 + 492 WP_001286801.1 PH domain-containing protein -
E3S85_RS13340 2719816..2720175 + 360 WP_000581197.1 holo-ACP synthase -
E3S85_RS13345 2720241..2721389 + 1149 WP_001281140.1 alanine racemase -
E3S85_RS13350 2721474..2721644 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
E3S85_RS13355 2721641..2722003 + 363 WP_000621176.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E3S85_RS13360 2722353..2723354 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
E3S85_RS13365 2723473..2723799 + 327 WP_001052491.1 anti-sigma factor antagonist -
E3S85_RS13370 2723801..2724280 + 480 WP_001190825.1 anti-sigma B factor RsbW -
E3S85_RS13375 2724255..2725025 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T148224 WP_000621176.1 NZ_CP047839:2721641-2722003 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

>T148224 NZ_CP063476:3918972-3919079 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT148224 WP_000948331.1 NZ_CP047839:2721474-2721644 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT148224 NZ_CP063476:c3918923-3918860 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168PYX0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References