Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2700753..2701267 Replicon chromosome
Accession NZ_CP047839
Organism Staphylococcus aureus strain UP_678

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag E3S85_RS13260 Protein ID WP_000581791.1
Coordinates 2701058..2701267 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag E3S85_RS13255 Protein ID WP_000138934.1
Coordinates 2700753..2701046 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S85_RS13225 2696216..2696857 + 642 WP_000483150.1 thiamine phosphate synthase -
E3S85_RS13230 2696943..2697815 + 873 WP_000725802.1 membrane protein insertase YidC -
E3S85_RS13235 2697972..2698271 - 300 WP_001793952.1 hypothetical protein -
E3S85_RS13245 2698428..2699075 - 648 WP_001187612.1 HD domain-containing protein -
E3S85_RS13250 2699103..2700587 - 1485 WP_033845100.1 cardiolipin synthase -
E3S85_RS13255 2700753..2701046 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3S85_RS13260 2701058..2701267 + 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
E3S85_RS13265 2701395..2701532 + 138 WP_000828354.1 hypothetical protein -
E3S85_RS13270 2701944..2702627 + 684 Protein_2574 transposase -
E3S85_RS13275 2702788..2703990 - 1203 WP_001109939.1 rod shape-determining protein RodA -
E3S85_RS13280 2704308..2705378 + 1071 WP_000159638.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T148223 WP_000581791.1 NZ_CP047839:2701058-2701267 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T148223 NZ_CP063476:3918490-3918597 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT148223 WP_000138934.1 NZ_CP047839:2700753-2701046 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT148223 NZ_CP063476:c3918441-3918378 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References