Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1180963..1181440 Replicon chromosome
Accession NZ_CP047837
Organism Staphylococcus aureus strain UP_719

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S86_RS05985 Protein ID WP_000052076.1
Coordinates 1181252..1181440 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S86_RS05980 Protein ID WP_001059690.1
Coordinates 1180963..1181223 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S86_RS05945 1176357..1177073 - 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -
E3S86_RS05950 1177221..1177643 + 423 WP_000974451.1 organic hydroperoxide resistance protein -
E3S86_RS05955 1178041..1178535 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S86_RS05960 1178691..1179308 + 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
E3S86_RS05965 1179381..1179962 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3S86_RS05970 1180186..1180422 + 237 WP_000368687.1 hypothetical protein -
E3S86_RS05975 1180419..1180622 - 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
E3S86_RS05980 1180963..1181223 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S86_RS05985 1181252..1181440 + 189 WP_000052076.1 hypothetical protein Toxin
E3S86_RS05990 1181628..1182197 + 570 WP_001106662.1 hypothetical protein -
E3S86_RS05995 1182285..1182557 + 273 WP_001004400.1 hypothetical protein -
E3S86_RS06000 1182630..1182848 + 219 WP_000005884.1 hypothetical protein -
E3S86_RS06005 1183345..1183545 - 201 WP_001059082.1 cold-shock protein -
E3S86_RS06010 1183902..1184588 - 687 WP_001622483.1 thermonuclease family protein -
E3S86_RS06015 1184929..1185450 - 522 WP_000824479.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp / sell / sec 1170670..1216846 46176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T148195 WP_000052076.1 NZ_CP047837:1181252-1181440 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148195 NZ_CP063473:c2588308-2588205 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148195 WP_001059690.1 NZ_CP047837:1180963-1181223 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148195 NZ_CP063473:2588167-2588438 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTAGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References