Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2678585..2679099 Replicon chromosome
Accession NZ_CP047835
Organism Staphylococcus aureus strain UP_883

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag E3S91_RS13180 Protein ID WP_000581792.1
Coordinates 2678890..2679099 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag E3S91_RS13175 Protein ID WP_000138932.1
Coordinates 2678585..2678878 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S91_RS13155 2674189..2674830 + 642 WP_000483153.1 thiamine phosphate synthase -
E3S91_RS13160 2674916..2675788 + 873 WP_000725802.1 membrane protein insertase YidC -
E3S91_RS13165 2676260..2676907 - 648 WP_001187629.1 HD domain-containing protein -
E3S91_RS13170 2676935..2678419 - 1485 WP_000571549.1 cardiolipin synthase -
E3S91_RS13175 2678585..2678878 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3S91_RS13180 2678890..2679099 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
E3S91_RS13185 2679227..2679364 + 138 WP_000828354.1 hypothetical protein -
E3S91_RS13190 2679628..2680830 - 1203 WP_001109941.1 rod shape-determining protein RodA -
E3S91_RS13195 2681148..2682218 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
E3S91_RS13200 2682233..2683591 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T148188 WP_000581792.1 NZ_CP047835:2678890-2679099 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T148188 NZ_CP063473:c1084102-1083884 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT148188 WP_000138932.1 NZ_CP047835:2678585-2678878 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT148188 NZ_CP063473:c1084502-1084128 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References