Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1174987..1175464 Replicon chromosome
Accession NZ_CP047835
Organism Staphylococcus aureus strain UP_883

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S91_RS05875 Protein ID WP_000052076.1
Coordinates 1175276..1175464 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S91_RS05870 Protein ID WP_001059690.1
Coordinates 1174987..1175247 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S91_RS05835 1170380..1171096 - 717 WP_000150018.1 type I 3-dehydroquinate dehydratase -
E3S91_RS05840 1171244..1171666 + 423 WP_000974455.1 organic hydroperoxide resistance protein -
E3S91_RS05845 1172065..1172559 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S91_RS05850 1172714..1173331 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
E3S91_RS05855 1173404..1173985 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
E3S91_RS05860 1174210..1174446 + 237 WP_000368687.1 hypothetical protein -
E3S91_RS05865 1174443..1174646 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3S91_RS05870 1174987..1175247 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S91_RS05875 1175276..1175464 + 189 WP_000052076.1 hypothetical protein Toxin
E3S91_RS05880 1175652..1176221 + 570 WP_001106655.1 hypothetical protein -
E3S91_RS05885 1176309..1176593 + 285 WP_001004399.1 hypothetical protein -
E3S91_RS05890 1176655..1176873 + 219 WP_000005884.1 hypothetical protein -
E3S91_RS05895 1177368..1177568 - 201 WP_001059082.1 cold-shock protein -
E3S91_RS05900 1177925..1178611 - 687 WP_000141557.1 thermonuclease family protein -
E3S91_RS05905 1178952..1179473 - 522 WP_000824484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 1171244..1205734 34490


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T148179 WP_000052076.1 NZ_CP047835:1175276-1175464 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148179 NZ_CP063467:4177421-4177828 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148179 WP_001059690.1 NZ_CP047835:1174987-1175247 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148179 NZ_CP063467:4177174-4177440 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References