Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 120023..120799 Replicon chromosome
Accession NZ_CP047835
Organism Staphylococcus aureus strain UP_883

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag E3S91_RS00770 Protein ID WP_000031108.1
Coordinates 120647..120799 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag E3S91_RS00765 Protein ID WP_001251224.1
Coordinates 120023..120622 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S91_RS00745 115939..117396 + 1458 WP_000649908.1 ABC transporter permease subunit -
E3S91_RS00750 117389..118111 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
E3S91_RS00755 118262..119389 + 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
E3S91_RS00760 119394..119864 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
E3S91_RS00765 120023..120622 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
E3S91_RS00770 120647..120799 + 153 WP_000031108.1 hypothetical protein Toxin
E3S91_RS00775 121630..122025 + 396 WP_000901023.1 hypothetical protein -
E3S91_RS00780 122221..123606 + 1386 WP_000116229.1 class II fumarate hydratase -
E3S91_RS00785 124067..124888 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T148176 WP_000031108.1 NZ_CP047835:120647-120799 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T148176 NZ_CP063467:3545165-3545272 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAGCAAGCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT148176 WP_001251224.1 NZ_CP047835:120023-120622 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT148176 NZ_CP063467:c3545117-3545051 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References