Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1193827..1194304 Replicon chromosome
Accession NZ_CP047833
Organism Staphylococcus aureus strain UP_926

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S92_RS06035 Protein ID WP_000052076.1
Coordinates 1194116..1194304 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S92_RS06030 Protein ID WP_001059690.1
Coordinates 1193827..1194087 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S92_RS05995 1189220..1189936 - 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -
E3S92_RS06000 1190084..1190506 + 423 WP_000974451.1 organic hydroperoxide resistance protein -
E3S92_RS06005 1190905..1191399 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S92_RS06010 1191555..1192172 + 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
E3S92_RS06015 1192245..1192826 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3S92_RS06020 1193050..1193286 + 237 WP_000368687.1 hypothetical protein -
E3S92_RS06025 1193283..1193486 - 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
E3S92_RS06030 1193827..1194087 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S92_RS06035 1194116..1194304 + 189 WP_000052076.1 hypothetical protein Toxin
E3S92_RS06040 1194492..1195061 + 570 WP_001106662.1 hypothetical protein -
E3S92_RS06045 1195149..1195421 + 273 WP_001004400.1 hypothetical protein -
E3S92_RS06050 1195494..1195712 + 219 WP_000005884.1 hypothetical protein -
E3S92_RS06055 1196209..1196409 - 201 WP_001059082.1 cold-shock protein -
E3S92_RS06060 1196766..1197452 - 687 WP_001622483.1 thermonuclease family protein -
E3S92_RS06065 1197793..1198314 - 522 WP_000824479.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T148168 WP_000052076.1 NZ_CP047833:1194116-1194304 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148168 NZ_CP063467:c1218590-1218414 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148168 WP_001059690.1 NZ_CP047833:1193827-1194087 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148168 NZ_CP063467:c1218368-1217952 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References