Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2067206..2067720 Replicon chromosome
Accession NZ_CP047830
Organism Staphylococcus aureus strain UP_996

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag E3S94_RS10160 Protein ID WP_000581792.1
Coordinates 2067206..2067415 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag E3S94_RS10165 Protein ID WP_000138932.1
Coordinates 2067427..2067720 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S94_RS10140 2062714..2064072 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
E3S94_RS10145 2064087..2065157 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
E3S94_RS10150 2065475..2066677 + 1203 WP_001109939.1 rod shape-determining protein RodA -
E3S94_RS10155 2066941..2067078 - 138 WP_000828354.1 hypothetical protein -
E3S94_RS10160 2067206..2067415 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
E3S94_RS10165 2067427..2067720 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3S94_RS10170 2067886..2069370 + 1485 WP_160192522.1 cardiolipin synthase -
E3S94_RS10175 2069398..2070045 + 648 WP_001187629.1 HD domain-containing protein -
E3S94_RS10190 2070858..2071724 - 867 WP_064139140.1 membrane protein insertase YidC -
E3S94_RS10195 2071810..2072451 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T148158 WP_000581792.1 NZ_CP047830:c2067415-2067206 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T148158 NZ_CP063462:89213-89518 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT148158 WP_000138932.1 NZ_CP047830:c2067720-2067427 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT148158 NZ_CP063462:88993-89211 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References