Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2672877..2673406 Replicon chromosome
Accession NZ_CP047828
Organism Staphylococcus aureus strain UP_1073

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E3S96_RS13135 Protein ID WP_000621175.1
Coordinates 2673044..2673406 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag E3S96_RS13130 Protein ID WP_000948331.1
Coordinates 2672877..2673047 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S96_RS13100 2667914..2668474 + 561 WP_001092406.1 K(+)-transporting ATPase subunit C -
E3S96_RS13105 2668682..2669161 + 480 WP_001287077.1 hypothetical protein -
E3S96_RS13110 2669154..2670737 + 1584 WP_001294637.1 PH domain-containing protein -
E3S96_RS13115 2670724..2671215 + 492 WP_001205907.1 PH domain-containing protein -
E3S96_RS13120 2671219..2671578 + 360 WP_000581199.1 holo-ACP synthase -
E3S96_RS13125 2671644..2672792 + 1149 WP_001281140.1 alanine racemase -
E3S96_RS13130 2672877..2673047 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
E3S96_RS13135 2673044..2673406 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E3S96_RS13140 2673755..2674756 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
E3S96_RS13145 2674875..2675201 + 327 WP_160190625.1 anti-sigma factor antagonist -
E3S96_RS13150 2675203..2675682 + 480 WP_001190825.1 anti-sigma B factor RsbW -
E3S96_RS13155 2675657..2676427 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T148152 WP_000621175.1 NZ_CP047828:2673044-2673406 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T148152 NZ_CP063459:3797269-3797376 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT148152 WP_000948331.1 NZ_CP047828:2672877-2673047 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT148152 NZ_CP063459:c3797222-3797156 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References