Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1180882..1181359 Replicon chromosome
Accession NZ_CP047828
Organism Staphylococcus aureus strain UP_1073

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3S96_RS05980 Protein ID WP_000052076.1
Coordinates 1181171..1181359 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3S96_RS05975 Protein ID WP_001059690.1
Coordinates 1180882..1181142 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S96_RS05940 1176275..1176991 - 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -
E3S96_RS05945 1177139..1177561 + 423 WP_000974451.1 organic hydroperoxide resistance protein -
E3S96_RS05950 1177960..1178454 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3S96_RS05955 1178610..1179227 + 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
E3S96_RS05960 1179300..1179881 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3S96_RS05965 1180105..1180341 + 237 WP_000368687.1 hypothetical protein -
E3S96_RS05970 1180338..1180541 - 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
E3S96_RS05975 1180882..1181142 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3S96_RS05980 1181171..1181359 + 189 WP_000052076.1 hypothetical protein Toxin
E3S96_RS05985 1181547..1182116 + 570 WP_001106662.1 hypothetical protein -
E3S96_RS05990 1182204..1182476 + 273 WP_001004400.1 hypothetical protein -
E3S96_RS05995 1182549..1182767 + 219 WP_000005875.1 hypothetical protein -
E3S96_RS06000 1183264..1183464 - 201 WP_001059082.1 cold-shock protein -
E3S96_RS06005 1183821..1184507 - 687 WP_001622483.1 thermonuclease family protein -
E3S96_RS06010 1184848..1185369 - 522 WP_000824479.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 1102657..1199221 96564


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)

Antitoxin

Toxin YoeB

(5-84)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T148148 WP_000052076.1 NZ_CP047828:1181171-1181359 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148148 NZ_CP063459:2963706-2963957 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148148 WP_001059690.1 NZ_CP047828:1180882-1181142 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148148 NZ_CP063459:2963954-2964208 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References