Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1168408..1168885 Replicon chromosome
Accession NZ_CP047826
Organism Staphylococcus aureus strain UP_1239

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3T01_RS05820 Protein ID WP_000052076.1
Coordinates 1168697..1168885 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3T01_RS05815 Protein ID WP_001059690.1
Coordinates 1168408..1168668 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T01_RS05780 1163803..1164519 - 717 WP_000150021.1 type I 3-dehydroquinate dehydratase -
E3T01_RS05785 1164667..1165089 + 423 WP_000974447.1 organic hydroperoxide resistance protein -
E3T01_RS05790 1165488..1165982 + 495 WP_064626748.1 GNAT family N-acetyltransferase -
E3T01_RS05795 1166136..1166753 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
E3T01_RS05800 1166826..1167407 - 582 WP_001140690.1 phosphoglycerate mutase family protein -
E3T01_RS05805 1167632..1167868 + 237 WP_000368687.1 hypothetical protein -
E3T01_RS05810 1167865..1168068 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3T01_RS05815 1168408..1168668 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3T01_RS05820 1168697..1168885 + 189 WP_000052076.1 hypothetical protein Toxin
E3T01_RS05825 1169073..1169642 + 570 WP_001106654.1 hypothetical protein -
E3T01_RS05830 1169730..1170014 + 285 WP_001004395.1 hypothetical protein -
E3T01_RS05835 1170076..1170294 + 219 WP_000005889.1 hypothetical protein -
E3T01_RS05840 1170789..1170989 - 201 WP_001059082.1 cold-shock protein -
E3T01_RS05845 1171346..1172032 - 687 WP_001641381.1 thermonuclease family protein -
E3T01_RS05850 1172373..1172882 - 510 WP_000824480.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T148132 WP_000052076.1 NZ_CP047826:1168697-1168885 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148132 NZ_CP063455:c5663196-5662798 [Pseudomonas protegens]
ATGCTCAAGTACATGCTGGATACCAATATCTGCATCTTTACCATCAAGAACAAACCTGAACAGGTTCGCGACGCGTTCAG
GCGTCATCAGGGGCGTTTGTGCATCAGCACCATCACCTTGATGGAGCTGATTTACGGTGCGGAAAAATCTGCCATCCCCG
AAAGGAATCTCAGCCGCGTCGAGAGTTTTGTGGCGCGGTTGCAGGTGCTTGATTATGACGATGTCGCCGCCATCCATAGC
GGCCAGTTGCATGCTGAGCTGGCCCGACAGGGCAAGCAGATAGGTCCTTACGATCAATTGATAGCTGGCCACGCTCGATC
TTTGGGGTTGACGCTGATTACCAACAACCTTCGGGAATTTGAGCGTGTTCCTGGCTTGCGGGTTGAGGATTGGGTCTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148132 WP_001059690.1 NZ_CP047826:1168408-1168668 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148132 NZ_CP063455:c5663429-5663196 [Pseudomonas protegens]
ATGGAAACCGGTTCAGTGTTCAAAAGTAATCGCAGCCAGGCCATTCGCATGCCTAAAGCTGTCGCGCTGCCGGATGATGT
CACACGGGTAGACATCGTCGCGATTGGTCGCACCCGTATCATTACCCCGGCGGGGGAGTCCTGGGACAGTTGGTTCGACG
AGGACGACCGTGTAAGCGCTGACTTCATGAATGAACGGGACCAGCCAGCCGAGCAAGTGCGTGAGGAGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References