Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2718730..2719244 Replicon chromosome
Accession NZ_CP047822
Organism Staphylococcus aureus strain UP_1278

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag E3T02_RS13460 Protein ID WP_000581792.1
Coordinates 2719035..2719244 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag E3T02_RS13455 Protein ID WP_000138932.1
Coordinates 2718730..2719023 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T02_RS13435 2714340..2714981 + 642 WP_000483153.1 thiamine phosphate synthase -
E3T02_RS13440 2715067..2715939 + 873 WP_000725802.1 membrane protein insertase YidC -
E3T02_RS13445 2716405..2717052 - 648 WP_001187630.1 HD domain-containing protein -
E3T02_RS13450 2717080..2718564 - 1485 WP_000571549.1 cardiolipin synthase -
E3T02_RS13455 2718730..2719023 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3T02_RS13460 2719035..2719244 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
E3T02_RS13465 2719372..2719509 + 138 WP_000828354.1 hypothetical protein -
E3T02_RS13470 2719773..2720975 - 1203 WP_045173480.1 rod shape-determining protein RodA -
E3T02_RS13475 2721293..2722363 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
E3T02_RS13480 2722378..2723736 + 1359 WP_006190765.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T148126 WP_000581792.1 NZ_CP047822:2719035-2719244 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T148126 NZ_CP063455:c1879807-1879499 [Pseudomonas protegens]
ATGACCCAGATATTGACCCACTTCGACATGGCCGAGTTGCTGGACAGCGACCAGGCCATCGCAGAGTACCTGTCACAAGT
GCTGGCCGACGGTGATACCGAGGAGTTTCTTCGAGCCATCGGCTACGTAGCCAAAGCTCGGGGTATGTCCCAGATTGCCC
GGGATGCCGGGATGGGCCGGGAAAGCCTGTACAAGGCTTTTGCCCCGGGCTCAAAACCGCGATTCGACACCGTCTTGAAG
GTCATTCATGCCTTGGGGATCGATCTGCAGGCCCAGCCAGGGCATGTGGAGAAACCCAAGGCCAGTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT148126 WP_000138932.1 NZ_CP047822:2718730-2719023 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT148126 NZ_CP063455:c1880103-1879804 [Pseudomonas protegens]
ATGAAATATCTCATCCAACAAACCCAGTCCTTTGCCAGATGGCACTCATCACTGAAGGACTTGCGCGCAAAAATCTCCAT
TGCCCGCCGCATCGATCGCGCTGCAACAGGCAATCTGGGGGATGTGAAATCCGTGGGAGAAGGTATTTCGGAACTGCGCG
TGGACGTGGGTCCCGGGTATCGGCTGTACTTCACCCAGCGTGGCGGCGTGATCATTGTGTTGCTGGCAGGCGGGGACAAA
TCCTCTCAAGACGCGGACATTCGCCGGGCAAAGATATTGGCAAAGGACCTTTCAACATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References