Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1243621..1244098 Replicon chromosome
Accession NZ_CP047822
Organism Staphylococcus aureus strain UP_1278

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3T02_RS06300 Protein ID WP_000052076.1
Coordinates 1243910..1244098 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3T02_RS06295 Protein ID WP_001059690.1
Coordinates 1243621..1243881 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T02_RS06265 1239365..1240537 + 1173 WP_000195429.1 IS256-like element IS256 family transposase -
E3T02_RS06270 1240699..1241193 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3T02_RS06275 1241348..1241965 + 618 WP_000255557.1 LysE/ArgO family amino acid transporter -
E3T02_RS06280 1242038..1242619 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3T02_RS06285 1242844..1243080 + 237 WP_000368687.1 hypothetical protein -
E3T02_RS06290 1243077..1243280 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3T02_RS06295 1243621..1243881 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3T02_RS06300 1243910..1244098 + 189 WP_000052076.1 hypothetical protein Toxin
E3T02_RS06305 1244286..1244855 + 570 WP_001106652.1 hypothetical protein -
E3T02_RS06310 1244943..1245227 + 285 WP_001004394.1 hypothetical protein -
E3T02_RS06315 1245289..1245507 + 219 WP_000005884.1 hypothetical protein -
E3T02_RS06320 1246002..1246202 - 201 WP_001059082.1 cold-shock protein -
E3T02_RS06325 1246559..1247245 - 687 WP_001792695.1 thermonuclease family protein -
E3T02_RS06330 1247586..1248107 - 522 WP_042909090.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1239365..1240537 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T148117 WP_000052076.1 NZ_CP047822:1243910-1244098 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148117 NZ_CP063450:c4942754-4942455 [Rhodococcus pyridinivorans]
ATGCGGCCGATTCACGCCGCGAAGCTGGACAAGACGCGGCCGGTGTTGGTGTTGACCCGCGAGTTGGTGCGTCCGCACCT
GGGCAGGGTGACGGTGGCGCCGATCACCGGCACCGTGCGGGGGTTGTCGACAGAGGTGCCGGTGGGCCCGGCGAACGGAT
TGGAGAAGGATTCGGTGGTCAGTTGCGACAACATCGTCACCATTCCGGTGTCGGCGTTGGGGCGCAGTCTCGGGTTTTTC
TTTCCGGCGCAGGAAGCGGCGCTGTCCGAGGCGATTCGGGCCGCGTTCGACCTCGAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148117 WP_001059690.1 NZ_CP047822:1243621-1243881 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148117 NZ_CP063450:c4942996-4942754 [Rhodococcus pyridinivorans]
ATGAGTACGCAGATTGCGGTGCGCTTGCCGGATGAGATTGTGGCTTTCGTCGATGAGGAGGTGCGGGAGCATCGGGCTCC
CAGTCGTGCGGCGCTGGTGTTGCGGGCGCTCGAACGGGAGCGGCGTCGGCGGATCGCCGCCCGCGATGTCGAGATTCTGT
CCCGGGCTCGCGGTGAAGCGGATCCGGACGAGTTCGATGGGCTCGCACGATATGCCGCAGGCCTGTCGAGCGATCTCGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References