Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2684356..2684885 Replicon chromosome
Accession NZ_CP047820
Organism Staphylococcus aureus strain UP_1395

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E3T05_RS13260 Protein ID WP_000621175.1
Coordinates 2684523..2684885 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag E3T05_RS13255 Protein ID WP_000948331.1
Coordinates 2684356..2684526 (+) Length 57 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T05_RS13225 2679393..2679953 + 561 WP_001092411.1 K(+)-transporting ATPase subunit C -
E3T05_RS13230 2680161..2680640 + 480 WP_001287088.1 hypothetical protein -
E3T05_RS13235 2680633..2682216 + 1584 WP_001294626.1 PH domain-containing protein -
E3T05_RS13240 2682203..2682694 + 492 WP_001205910.1 PH domain-containing protein -
E3T05_RS13245 2682698..2683057 + 360 WP_000581200.1 holo-ACP synthase -
E3T05_RS13250 2683123..2684271 + 1149 WP_001281145.1 alanine racemase -
E3T05_RS13255 2684356..2684526 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
E3T05_RS13260 2684523..2684885 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E3T05_RS13265 2685234..2686235 + 1002 WP_160192258.1 PP2C family protein-serine/threonine phosphatase -
E3T05_RS13270 2686354..2686680 + 327 WP_001052491.1 anti-sigma factor antagonist -
E3T05_RS13275 2686682..2687161 + 480 WP_001190829.1 anti-sigma B factor RsbW -
E3T05_RS13280 2687136..2687906 + 771 WP_001041103.1 RNA polymerase sigma factor SigB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-110)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T148112 WP_000621175.1 NZ_CP047820:2684523-2684885 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T148112 NZ_CP063442:c84364-83879 [Enterobacter asburiae]
GTGGGACGTTTAACAGCTCCGGAACCGTTATCCAGCTCACATCAACTGGCTGAGTTCGTAAGCGGGGAGGCCGTTCTCGA
TGACTGGCTTAAACAGCGAGGGTTAAAAAATCAGGCTCTTGGTGCTGCCAGAACGTTTGTTGTATGTAAAACAGGCACCA
AACAGGTTGCCGGTTTTTACTCCCTGGCCACCGGCAGCGTTAACCATGTAGAAGCGACGGGAGGTCTCAGGCGCAATATG
CCAGATCCAATCCCAGTAATCATACTTTCTCGCCTGGCGGTTGATACCTCATTTCGTGGACAAGGAGTTGGTGCTGATTT
ACTGCACAATGCGGTATTGCGTTGTTATCGTGTGTCTGAAAATATAGGCGTTCGTGCAATTATGGTTCATGCGCTGACAG
AAAAAGCCAAAGGGTTTTATCTCCATCATGGTTTTAAGGCATCGCAAACCCAGGAACGGACTCTGTTTCTCAAGCTACCG
CAGTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT148112 WP_000948331.1 NZ_CP047820:2684356-2684526 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT148112 NZ_CP063442:c84639-84352 [Enterobacter asburiae]
TTGCTATACAAGGGGGCACTAATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCTCAAAGAGCACTCATCGA
TGCTGCTGCAGAGATACTTCATAAATCACGTACGGATTTCATTCTGGAGATGGCATGCCAGGCTGCGGAGAATGTGATCC
TCGATCGACGTGTATTTAATTTTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCGCCAGTTGCGGATGAC
GCTGCCATCAATAAACTCCTGGCAAGGAAACCTCAGTGGGACGTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References