Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 2684356..2684885 | Replicon | chromosome |
Accession | NZ_CP047820 | ||
Organism | Staphylococcus aureus strain UP_1395 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | - |
Locus tag | E3T05_RS13260 | Protein ID | WP_000621175.1 |
Coordinates | 2684523..2684885 (+) | Length | 121 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | T1YCG8 |
Locus tag | E3T05_RS13255 | Protein ID | WP_000948331.1 |
Coordinates | 2684356..2684526 (+) | Length | 57 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E3T05_RS13225 | 2679393..2679953 | + | 561 | WP_001092411.1 | K(+)-transporting ATPase subunit C | - |
E3T05_RS13230 | 2680161..2680640 | + | 480 | WP_001287088.1 | hypothetical protein | - |
E3T05_RS13235 | 2680633..2682216 | + | 1584 | WP_001294626.1 | PH domain-containing protein | - |
E3T05_RS13240 | 2682203..2682694 | + | 492 | WP_001205910.1 | PH domain-containing protein | - |
E3T05_RS13245 | 2682698..2683057 | + | 360 | WP_000581200.1 | holo-ACP synthase | - |
E3T05_RS13250 | 2683123..2684271 | + | 1149 | WP_001281145.1 | alanine racemase | - |
E3T05_RS13255 | 2684356..2684526 | + | 171 | WP_000948331.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
E3T05_RS13260 | 2684523..2684885 | + | 363 | WP_000621175.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
E3T05_RS13265 | 2685234..2686235 | + | 1002 | WP_160192258.1 | PP2C family protein-serine/threonine phosphatase | - |
E3T05_RS13270 | 2686354..2686680 | + | 327 | WP_001052491.1 | anti-sigma factor antagonist | - |
E3T05_RS13275 | 2686682..2687161 | + | 480 | WP_001190829.1 | anti-sigma B factor RsbW | - |
E3T05_RS13280 | 2687136..2687906 | + | 771 | WP_001041103.1 | RNA polymerase sigma factor SigB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 121 a.a. Molecular weight: 13441.69 Da Isoelectric Point: 10.1654
>T148112 WP_000621175.1 NZ_CP047820:2684523-2684885 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN
Download Length: 363 bp
>T148112 NZ_CP063442:c84364-83879 [Enterobacter asburiae]
GTGGGACGTTTAACAGCTCCGGAACCGTTATCCAGCTCACATCAACTGGCTGAGTTCGTAAGCGGGGAGGCCGTTCTCGA
TGACTGGCTTAAACAGCGAGGGTTAAAAAATCAGGCTCTTGGTGCTGCCAGAACGTTTGTTGTATGTAAAACAGGCACCA
AACAGGTTGCCGGTTTTTACTCCCTGGCCACCGGCAGCGTTAACCATGTAGAAGCGACGGGAGGTCTCAGGCGCAATATG
CCAGATCCAATCCCAGTAATCATACTTTCTCGCCTGGCGGTTGATACCTCATTTCGTGGACAAGGAGTTGGTGCTGATTT
ACTGCACAATGCGGTATTGCGTTGTTATCGTGTGTCTGAAAATATAGGCGTTCGTGCAATTATGGTTCATGCGCTGACAG
AAAAAGCCAAAGGGTTTTATCTCCATCATGGTTTTAAGGCATCGCAAACCCAGGAACGGACTCTGTTTCTCAAGCTACCG
CAGTAG
GTGGGACGTTTAACAGCTCCGGAACCGTTATCCAGCTCACATCAACTGGCTGAGTTCGTAAGCGGGGAGGCCGTTCTCGA
TGACTGGCTTAAACAGCGAGGGTTAAAAAATCAGGCTCTTGGTGCTGCCAGAACGTTTGTTGTATGTAAAACAGGCACCA
AACAGGTTGCCGGTTTTTACTCCCTGGCCACCGGCAGCGTTAACCATGTAGAAGCGACGGGAGGTCTCAGGCGCAATATG
CCAGATCCAATCCCAGTAATCATACTTTCTCGCCTGGCGGTTGATACCTCATTTCGTGGACAAGGAGTTGGTGCTGATTT
ACTGCACAATGCGGTATTGCGTTGTTATCGTGTGTCTGAAAATATAGGCGTTCGTGCAATTATGGTTCATGCGCTGACAG
AAAAAGCCAAAGGGTTTTATCTCCATCATGGTTTTAAGGCATCGCAAACCCAGGAACGGACTCTGTTTCTCAAGCTACCG
CAGTAG
Antitoxin
Download Length: 57 a.a. Molecular weight: 6251.78 Da Isoelectric Point: 3.8305
>AT148112 WP_000948331.1 NZ_CP047820:2684356-2684526 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE
Download Length: 171 bp
>AT148112 NZ_CP063442:c84639-84352 [Enterobacter asburiae]
TTGCTATACAAGGGGGCACTAATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCTCAAAGAGCACTCATCGA
TGCTGCTGCAGAGATACTTCATAAATCACGTACGGATTTCATTCTGGAGATGGCATGCCAGGCTGCGGAGAATGTGATCC
TCGATCGACGTGTATTTAATTTTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCGCCAGTTGCGGATGAC
GCTGCCATCAATAAACTCCTGGCAAGGAAACCTCAGTGGGACGTTTAA
TTGCTATACAAGGGGGCACTAATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCTCAAAGAGCACTCATCGA
TGCTGCTGCAGAGATACTTCATAAATCACGTACGGATTTCATTCTGGAGATGGCATGCCAGGCTGCGGAGAATGTGATCC
TCGATCGACGTGTATTTAATTTTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCGCCAGTTGCGGATGAC
GCTGCCATCAATAAACTCCTGGCAAGGAAACCTCAGTGGGACGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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