Detailed information of TA system TA148102

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1178594..1179071
• Replicon: chromosome
• Accession: NZ_CP047820
• Organism: Staphylococcus aureus strain UP_1395

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q2G005
• Locus tag: E3T05_RS05890
• Protein ID: WP_000052078.1
• Coordinates: 1178883..1179071 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: E3T05_RS05885
• Protein ID: WP_001059690.1
• Coordinates: 1178594..1178854 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T05_RS05850	1173987..1174703	-	717	WP_000150017.1	type I 3-dehydroquinate dehydratase	-
E3T05_RS05855	1174851..1175273	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
E3T05_RS05860	1175672..1176166	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
E3T05_RS05865	1176321..1176938	+	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
E3T05_RS05870	1177011..1177592	-	582	WP_001140686.1	phosphoglycerate mutase family protein	-
E3T05_RS05875	1177817..1178053	+	237	WP_000368687.1	hypothetical protein	-
E3T05_RS05880	1178050..1178253	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
E3T05_RS05885	1178594..1178854	+	261	WP_001059690.1	hypothetical protein	Antitoxin
E3T05_RS05890	1178883..1179071	+	189	WP_000052078.1	hypothetical protein	Toxin
E3T05_RS05895	1179259..1179828	+	570	WP_001106654.1	hypothetical protein	-
E3T05_RS05900	1179916..1180200	+	285	WP_001004395.1	hypothetical protein	-
E3T05_RS05905	1180262..1180480	+	219	WP_000005886.1	hypothetical protein	-
E3T05_RS05910	1180718..1181203	-	486	WP_000093392.1	IS200/IS605 family transposase	-
E3T05_RS05915	1181718..1181918	-	201	WP_001059082.1	cold-shock protein	-
E3T05_RS05920	1182275..1182961	-	687	WP_001548082.1	thermonuclease family protein	-
E3T05_RS05925	1183302..1183767	-	466	Protein_1135	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp	1175672..1185124	9452
	-	flank	IS/Tn	-	-	1180718..1181203	485

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (9-56)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7172.84 Da
• Isoelectric Point: 9.9971

>T148102 WP_000052078.1 NZ_CP047820:1178883-1179071 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T148102 NZ_CP063440:c3741851-3741432 [Proteus mirabilis]
GTGAAAAAAGTCTATATGCTTGATACAAACATTTGTTCTTTTATCATGCGAGAGCAACCTATTTCTTTGCTCGAAAAACT
TCAGAAATGTGTAATGAACCACGATACTATTGTCATATCAGCGATTACTTATTCAGAGATGCGCTTTGGAGCAATAGGAA
AAAAAGCATCACCTAAACACAATCGTTTGGTTGATGCTTTCTGTGAACGCGTTGACGCGATTTTGGCATGGGATAAAGCG
GCGGTAGACGCAACTACCGTGATAAAAAAATGCTTATCTGATGTGGGATTGCCCATAGGAAATAATGATAGCGCGATTGC
TGGTCATGCTGTCGCGGTTAATGCAATATTGGTAACAAATAATACCCGTGAATTTTCACGAGTTGAAGGACTAAAAATAG
AGGACTGGACTCATGTTTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT148102 WP_001059690.1 NZ_CP047820:1178594-1178854 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT148102 NZ_CP063440:c3742081-3741848 [Proteus mirabilis]
ATGAGAACGAGAACTGTAGCTGTATTTAAAAACGGAAGTAACCGAGCCATTCGCTTACCTAAAGATTTCGATTTTGATGG
TGTCAATGAACTCGAGATAAGCCGAGATGGGGATTGTATTATTTTACGCCCTGTAAAACCTAACTGGATTTCATTACAAA
ACGAAGAAAAAGCCGACAGTGATTTCTTGCTTGAACGCGATGATGTTATTGAAGAAGGACGAGTTATTCTGTGA

Structures

Toxin

• AlphaFold DB: A0A0D6HZ40

Antitoxin

• AlphaFold DB: A0A0E0VN56