148094

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2645765..2646279 Replicon chromosome
Accession NZ_CP047817
Organism Staphylococcus aureus strain UP_1433

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag E3T06_RS13005 Protein ID WP_000581792.1
Coordinates 2646070..2646279 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag E3T06_RS13000 Protein ID WP_000138932.1
Coordinates 2645765..2646058 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T06_RS12965 2640928..2641569 + 642 WP_000483153.1 thiamine phosphate synthase -
E3T06_RS12970 2641655..2642527 + 873 WP_000725802.1 membrane protein insertase YidC -
E3T06_RS12990 2643440..2644087 - 648 WP_001187630.1 HD domain-containing protein -
E3T06_RS12995 2644115..2645599 - 1485 WP_000571549.1 cardiolipin synthase -
E3T06_RS13000 2645765..2646058 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3T06_RS13005 2646070..2646279 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
E3T06_RS13010 2646407..2646544 + 138 WP_000828354.1 hypothetical protein -
E3T06_RS13015 2646808..2648010 - 1203 WP_001109939.1 rod shape-determining protein RodA -
E3T06_RS13020 2648328..2649398 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
E3T06_RS13025 2649413..2650771 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T148094 WP_000581792.1 NZ_CP047817:2646070-2646279 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T148094 NZ_CP063427:c3457242-3456910 [Citrobacter sp. BDA59-3]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGACCACCGGGCATGAACAAAGCGGAAAACGTCCAGTGCTTAT
CGTTTCTCCCGCGTCATTTAATGCACTCACCCGTTTGCCCGTTGTTGTTCCGGTCACCAGTGGCGGAAACTTTGCCCGAG
CGGCGGGTTTTGCCGTCTCACTGGACGGTGCGGGAACGAAAACCACGGGTGTGATTCGCTGCGATCAGCCCAGAACCATT
GATATGGACGCCCGAAACGGCAAGCGTCTGGAACGTATACCCGATGCTGTCGTGAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT148094 WP_000138932.1 NZ_CP047817:2645765-2646058 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT148094 NZ_CP063427:c3457500-3457243 [Citrobacter sp. BDA59-3]
ATGTATATCGCTCGCCTTAAAAAGGTTGGAGGATCCGTCATGCTGGCGGTTCCTCCTGCCGTATTGAAAACCCTGGGGCT
GTCGACGGATAGCGAAGTGGGTATGACCATTGAGAATGGTTGCCTGATTATTGAACCCCAGAAACGGCCACATTACTCGC
TTGAGGAATTGCTGGCGCAGTGTGATCCGCACGCCGAAATCAGCGAAGAGGATCGGCAATGGATTGATGCGCCTGCGGCG
GGCAAGGAACTTCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References