Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2270459..2270982 Replicon chromosome
Accession NZ_CP047817
Organism Staphylococcus aureus strain UP_1433

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag E3T06_RS11060 Protein ID WP_000074049.1
Coordinates 2270716..2270982 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag E3T06_RS11055 Protein ID WP_000587616.1
Coordinates 2270459..2270716 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T06_RS11040 2266956..2267705 - 750 WP_000072462.1 CPBP family intramembrane metalloprotease -
E3T06_RS11045 2267900..2269477 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
E3T06_RS11050 2269645..2270100 - 456 WP_000732076.1 DUF1307 domain-containing protein -
E3T06_RS11055 2270459..2270716 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3T06_RS11060 2270716..2270982 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
E3T06_RS11065 2271337..2272413 + 1077 WP_001076673.1 M42 family metallopeptidase -
E3T06_RS11070 2272661..2273323 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
E3T06_RS11075 2273316..2274092 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
E3T06_RS11080 2274488..2275675 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T148086 WP_000074049.1 NZ_CP047817:2270716-2270982 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T148086 NZ_CP063425:c3028359-3028021 [Kosakonia pseudosacchari]
ATGACGCAGACGTTTGAAAAATGGTTTGATGCACTGGGGGATAACGATCGCGCCAGTGTGCTGGCGGCGCTGATGGTACT
TCGGGTTAAAGGCCCGCAGCTACCAAGGCCTTATGCGGATACGGTAAAAGGCTCGCGTTATAACAATATGAAGGAGCTAC
GCATACAAAGCCGGGGCGAGCCGTTTCGGGTCTTCTATGCCTTTGATCCGCAGCGCGTGGGCATATTGCTTTGCGCTGGC
AACAAGGCGAGTCATGAGAAACGCTTTTACGATGTGATGATCCAGATTGCAGATCGGGAGCTAACGCACCATCTGCACAA
GATAAAAATTAAGGAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT148086 WP_000587616.1 NZ_CP047817:2270459-2270716 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT148086 NZ_CP063425:c3028016-3027714 [Kosakonia pseudosacchari]
ATGAGCAAAACGCTGGAACAGCTAATTGCCGAACAAAAGGCCGAGGTTGTCACCGCTGCGCAGTCACTCGCGCAAGAGAT
GCTGCTCAATATCCACCTTGCCGAGCTGCGTGAGCGGGTACAAAAAACGCAGATTGAAATGGCGCAGGAGTTGGGGCTGA
AACAGCCCACGGTCGCCGTGATGGAAAAGCAAGGGCGGGATATTAAACTTTCCACGCTGAAGCGCTACGTGGAAGCGACA
GGCAGCAAGCTACGCATTGATATTGAGCTGCCGGATGGCTCGCACTATGGCTTTGCGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References