Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1175628..1176105 Replicon chromosome
Accession NZ_CP047817
Organism Staphylococcus aureus strain UP_1433

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3T06_RS05890 Protein ID WP_000052076.1
Coordinates 1175917..1176105 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3T06_RS05885 Protein ID WP_001059690.1
Coordinates 1175628..1175888 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T06_RS05850 1171021..1171737 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
E3T06_RS05855 1171885..1172307 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
E3T06_RS05860 1172706..1173200 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3T06_RS05865 1173355..1173972 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
E3T06_RS05870 1174045..1174626 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
E3T06_RS05875 1174851..1175087 + 237 WP_000349581.1 hypothetical protein -
E3T06_RS05880 1175084..1175287 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3T06_RS05885 1175628..1175888 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3T06_RS05890 1175917..1176105 + 189 WP_000052076.1 hypothetical protein Toxin
E3T06_RS05895 1176293..1176862 + 570 WP_001106654.1 hypothetical protein -
E3T06_RS05900 1176950..1177234 + 285 WP_001004399.1 hypothetical protein -
E3T06_RS05905 1177296..1177514 + 219 WP_000005886.1 hypothetical protein -
E3T06_RS05910 1178006..1178206 - 201 WP_001059082.1 cold-shock protein -
E3T06_RS05915 1178563..1179249 - 687 WP_000141557.1 thermonuclease family protein -
E3T06_RS05920 1179592..1180113 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - seb / vWbp 1146550..1189701 43151


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T148085 WP_000052076.1 NZ_CP047817:1175917-1176105 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148085 NZ_CP063425:c2869429-2869327 [Kosakonia pseudosacchari]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTTTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148085 WP_001059690.1 NZ_CP047817:1175628-1175888 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148085 NZ_CP063425:2869323-2869489 [Kosakonia pseudosacchari]
AGATAAAAAAAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCACTTTAAGAATAGATGACGGCGTCAGGTTTTCCAGTCCGCGACAAAAGTGGTC
AGAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References