Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2058052..2058566 Replicon chromosome
Accession NZ_CP047815
Organism Staphylococcus aureus strain UP_1484

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag E3T08_RS10015 Protein ID WP_000581792.1
Coordinates 2058052..2058261 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag E3T08_RS10020 Protein ID WP_000138932.1
Coordinates 2058273..2058566 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T08_RS09995 2053560..2054918 - 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
E3T08_RS10000 2054933..2056003 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
E3T08_RS10005 2056321..2057523 + 1203 WP_001109939.1 rod shape-determining protein RodA -
E3T08_RS10010 2057787..2057924 - 138 WP_000828354.1 hypothetical protein -
E3T08_RS10015 2058052..2058261 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
E3T08_RS10020 2058273..2058566 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3T08_RS10025 2058732..2060216 + 1485 WP_000571549.1 cardiolipin synthase -
E3T08_RS10030 2060244..2060891 + 648 WP_001187634.1 HD domain-containing protein -
E3T08_RS10040 2061619..2062491 - 873 WP_000725802.1 membrane protein insertase YidC -
E3T08_RS10045 2062577..2063218 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T148072 WP_000581792.1 NZ_CP047815:c2058261-2058052 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T148072 NZ_CP063421:244366-244698 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTGGCGA
GTAAAGGTAAGGGAAAGCGTAGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGACGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAGCAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT148072 WP_000138932.1 NZ_CP047815:c2058566-2058273 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT148072 NZ_CP063421:244685-244999 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCACGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCTGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References