Detailed information of TA system TA148071

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2038294..2038823
• Replicon: chromosome
• Accession: NZ_CP047815
• Organism: Staphylococcus aureus strain UP_1484

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: E3T08_RS09925
• Protein ID: WP_000621175.1
• Coordinates: 2038294..2038656 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: E3T08_RS09930
• Protein ID: WP_000948331.1
• Coordinates: 2038653..2038823 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T08_RS09905	2035273..2036043	-	771	WP_001041107.1	RNA polymerase sigma factor SigB	-
E3T08_RS09910	2036018..2036497	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
E3T08_RS09915	2036499..2036825	-	327	WP_001052491.1	anti-sigma factor antagonist	-
E3T08_RS09920	2036944..2037945	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
E3T08_RS09925	2038294..2038656	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
E3T08_RS09930	2038653..2038823	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
E3T08_RS09935	2038908..2040056	-	1149	WP_000130547.1	alanine racemase	-
E3T08_RS09940	2040122..2040481	-	360	WP_000581202.1	holo-ACP synthase	-
E3T08_RS09945	2040485..2040976	-	492	WP_001205912.1	PH domain-containing protein	-
E3T08_RS09950	2040963..2042546	-	1584	WP_001294620.1	PH domain-containing protein	-
E3T08_RS09955	2042539..2043018	-	480	WP_001287079.1	hypothetical protein	-
E3T08_RS09960	2043227..2043787	-	561	WP_001092409.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T148071 WP_000621175.1 NZ_CP047815:c2038656-2038294 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T148071 NZ_CP063421:232569-232835 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT148071 WP_000948331.1 NZ_CP047815:c2038823-2038653 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT148071 NZ_CP063421:232822-233067 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1