148069

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 816183..816660 Replicon chromosome
Accession NZ_CP047815
Organism Staphylococcus aureus strain UP_1484

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3T08_RS03880 Protein ID WP_000052076.1
Coordinates 816183..816371 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3T08_RS03885 Protein ID WP_001059690.1
Coordinates 816400..816660 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T08_RS03850 812174..812695 + 522 WP_042909090.1 hypothetical protein -
E3T08_RS03855 813036..813722 + 687 WP_001792695.1 thermonuclease family protein -
E3T08_RS03860 814079..814279 + 201 WP_001059082.1 cold-shock protein -
E3T08_RS03865 814774..814992 - 219 WP_042909089.1 hypothetical protein -
E3T08_RS03870 815054..815338 - 285 WP_001004394.1 hypothetical protein -
E3T08_RS03875 815426..815995 - 570 WP_001106652.1 hypothetical protein -
E3T08_RS03880 816183..816371 - 189 WP_000052076.1 hypothetical protein Toxin
E3T08_RS03885 816400..816660 - 261 WP_001059690.1 hypothetical protein Antitoxin
E3T08_RS03890 817001..817204 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3T08_RS03895 817201..817437 - 237 WP_000368687.1 hypothetical protein -
E3T08_RS03900 817662..818243 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3T08_RS03905 818316..818933 - 618 WP_000255557.1 LysE/ArgO family amino acid transporter -
E3T08_RS03910 819088..819582 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3T08_RS03915 819981..820403 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
E3T08_RS03920 820551..821267 + 717 WP_000150013.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T148069 WP_000052076.1 NZ_CP047815:c816371-816183 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148069 NZ_CP063421:c222910-222611 [Vibrio cholerae]
ATGAAACCATTTAATCTTACTGTCGCCGCTAAAGCCGATTTACGGGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATCGGTAAATCAT
GCGATGAAATTCGAGAGGGATACAGAAAATTTCCCCAAGGGAGCCACGTCATCTTTTATCAGCAAATCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTTGGCGCATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148069 WP_001059690.1 NZ_CP047815:c816660-816400 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148069 NZ_CP063421:c223149-222907 [Vibrio cholerae]
ATGGCTAAAAACACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGACGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAATTAC
TTGTTGAAGGTGAGCAAAGTGGTGATGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References