Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2635513..2636027 Replicon chromosome
Accession NZ_CP047813
Organism Staphylococcus aureus strain UP_1500

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag E3T09_RS12985 Protein ID WP_000581792.1
Coordinates 2635818..2636027 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag E3T09_RS12980 Protein ID WP_000138932.1
Coordinates 2635513..2635806 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T09_RS12950 2630876..2631517 + 642 WP_043044028.1 thiamine phosphate synthase -
E3T09_RS12955 2631603..2632475 + 873 WP_000725802.1 membrane protein insertase YidC -
E3T09_RS12970 2633188..2633835 - 648 WP_001187630.1 HD domain-containing protein -
E3T09_RS12975 2633863..2635347 - 1485 WP_043044026.1 cardiolipin synthase -
E3T09_RS12980 2635513..2635806 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3T09_RS12985 2635818..2636027 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
E3T09_RS12990 2636155..2636292 + 138 WP_000828354.1 hypothetical protein -
E3T09_RS12995 2636556..2637758 - 1203 WP_001109939.1 rod shape-determining protein RodA -
E3T09_RS13000 2638076..2639146 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
E3T09_RS13005 2639161..2640519 + 1359 WP_000611466.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T148067 WP_000581792.1 NZ_CP047813:2635818-2636027 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T148067 NZ_CP063421:c191952-191653 [Vibrio cholerae]
ATGAAACCATTTAATCTTACTGTCGCCGCTAAAGCCGATTTACGGGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATCGGTAAATCAT
GCGATGAAATTCGAGAGGGATACAGAAAATTTCCCCAAGGGAGCCACGTCATCTTTTATCAGCAAATCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTTGGCGCATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT148067 WP_000138932.1 NZ_CP047813:2635513-2635806 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT148067 NZ_CP063421:c192191-191949 [Vibrio cholerae]
ATGGCTAAAAACACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGACGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAATTAC
TTGTTGAAGGTGAGCAAAGTGGTGATGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References