Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2260866..2261389 Replicon chromosome
Accession NZ_CP047813
Organism Staphylococcus aureus strain UP_1500

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag E3T09_RS11035 Protein ID WP_000074049.1
Coordinates 2261123..2261389 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag E3T09_RS11030 Protein ID WP_000587616.1
Coordinates 2260866..2261123 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T09_RS11015 2257363..2258112 - 750 WP_043044945.1 CPBP family intramembrane metalloprotease -
E3T09_RS11020 2258307..2259884 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
E3T09_RS11025 2260052..2260507 - 456 WP_000732076.1 DUF1307 domain-containing protein -
E3T09_RS11030 2260866..2261123 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3T09_RS11035 2261123..2261389 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
E3T09_RS11040 2261744..2262820 + 1077 WP_001076671.1 M42 family metallopeptidase -
E3T09_RS11045 2263068..2263730 + 663 WP_043044946.1 ATP-binding cassette domain-containing protein -
E3T09_RS11050 2263723..2264499 + 777 WP_000072145.1 iron export ABC transporter permease subunit FetB -
E3T09_RS11055 2264895..2266082 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T148059 WP_000074049.1 NZ_CP047813:2261123-2261389 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T148059 NZ_CP063418:760320-760577 [Actinomyces sp. ZJ34]
TTGGCGTGGACGATTGAGGTTGCGGACAGCGCCGTTAAGGCGCTGCGCAAGATCGACCCGCAGGTGCGGCGGCGTATCTG
GAGCACGGTCCGTGAGGTTGCTGAGCTTGAGGACCCACGCTCCCGAGGCAAGGCGCTGACCGCTGACCTTCGTGGGCTGT
GGTGCTACCGTGCCGGGGACTGGCGGATTATCTGCGACATTGACGATGGTCGAGTTGTCGTGGTCGAGGTCGGGCGCCGA
TCTCGGGTCTACGGGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT148059 WP_000587616.1 NZ_CP047813:2260866-2261123 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT148059 NZ_CP063418:760109-760336 [Actinomyces sp. ZJ34]
ATGGTGACGTCTATACGGCTCGACCCGCAGATTGAGCGGCGGTACGAGGCGCTGGCGCGCCACACGCACAGGTCAAAGTC
TTTCTACCTGCGTCAGGCCATCGAGCAGGCTATCGACCGCATGGAGTTCGAGTACCGGGTGCTCAGCGCGGTTGAGGACG
TGCGCGCGGGCCGTATGAAGACCTACAGCCTGGACGAGGCGGAGACGCTCATTGGCGTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References