Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1155403..1155880 Replicon chromosome
Accession NZ_CP047813
Organism Staphylococcus aureus strain UP_1500

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3T09_RS05760 Protein ID WP_000052076.1
Coordinates 1155692..1155880 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3T09_RS05755 Protein ID WP_001059690.1
Coordinates 1155403..1155663 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T09_RS05720 1150796..1151512 - 717 WP_000150016.1 type I 3-dehydroquinate dehydratase -
E3T09_RS05725 1151660..1152082 + 423 WP_043044653.1 organic hydroperoxide resistance protein -
E3T09_RS05730 1152481..1152975 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3T09_RS05735 1153130..1153747 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
E3T09_RS05740 1153820..1154401 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
E3T09_RS05745 1154626..1154862 + 237 WP_000368687.1 hypothetical protein -
E3T09_RS05750 1154859..1155062 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3T09_RS05755 1155403..1155663 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3T09_RS05760 1155692..1155880 + 189 WP_000052076.1 hypothetical protein Toxin
E3T09_RS05765 1156068..1156637 + 570 WP_001106652.1 hypothetical protein -
E3T09_RS05770 1156725..1157009 + 285 WP_001004401.1 hypothetical protein -
E3T09_RS05775 1157071..1157289 + 219 WP_000005886.1 hypothetical protein -
E3T09_RS05780 1157785..1157985 - 201 WP_001059082.1 cold-shock protein -
E3T09_RS05785 1158342..1159028 - 687 WP_001641381.1 thermonuclease family protein -
E3T09_RS05790 1159369..1159914 - 546 WP_043044654.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-97)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-78)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T148058 WP_000052076.1 NZ_CP047813:1155692-1155880 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148058 NZ_CP063418:c758074-757778 [Actinomyces sp. ZJ34]
ATGGTTCTGGCACCGGAGCCGACGCCTCGGTTCAGACGTGATGTCAAGGCTCTCCGGAAGAAGCACGTGGACCTGGCACC
GCTGCGTGAGGTTATCGATCTCATCGTTGCCGACACTGATCAGGCTAGGGATGAGCTCGTCCGTCATCACGGCATGCATC
GTCTGCGTGGCCAGTGGGAGGCGAGCAATGAGTGCCACGTCGCCAACGCTGGTGACTGGCTGCTGATCTGGACTACCACT
CAGACGCAAGCGATCCTCCAGCGTACCGGTGGGCACGACGACCTCTTCGGGCACTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148058 WP_001059690.1 NZ_CP047813:1155403-1155663 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148058 NZ_CP063418:c758337-758074 [Actinomyces sp. ZJ34]
ATGGCAACGATCACTGTACGTGTTGAGGATTCCGTCAAGGAGGGTGTCACCCAGATTGCTGAGGACTTCGGGTTCGACCT
GTCGTCAGTGACCCGCGCCTTCTACCTTCAGATGATCCGGGAGCACCGTATTCCCCTTAACCTGTCCTACCCGCAGCCCA
GTGCCGCCAGTCGTGAGGCGATTGAGCAGACTCGGCAGATCATCGCTTCGGGTCAGCACACCTACGACACTGCTGAGGCG
ATGTACGAGGACCTGGGTCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References