Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2662588..2663102 Replicon chromosome
Accession NZ_CP047811
Organism Staphylococcus aureus strain UP_1522

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag E3T10_RS13165 Protein ID WP_000581795.1
Coordinates 2662893..2663102 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag E3T10_RS13160 Protein ID WP_000138930.1
Coordinates 2662588..2662881 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T10_RS13140 2658114..2658755 + 642 WP_000483162.1 thiamine phosphate synthase -
E3T10_RS13145 2658841..2659713 + 873 WP_000725802.1 membrane protein insertase YidC -
E3T10_RS13150 2660263..2660910 - 648 WP_001187625.1 HD domain-containing protein -
E3T10_RS13155 2660938..2662422 - 1485 WP_000571562.1 cardiolipin synthase -
E3T10_RS13160 2662588..2662881 + 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3T10_RS13165 2662893..2663102 + 210 WP_000581795.1 heavy-metal-associated domain-containing protein Toxin
E3T10_RS13170 2663230..2663367 + 138 WP_000828354.1 hypothetical protein -
E3T10_RS13175 2663631..2664833 - 1203 WP_001109939.1 rod shape-determining protein RodA -
E3T10_RS13180 2665151..2666221 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
E3T10_RS13185 2666236..2667594 + 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T148050 WP_000581795.1 NZ_CP047811:2662893-2663102 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T148050 NZ_CP063403:775159-775569 [Klebsiella variicola]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGTTGGTTCCCTGGCCGCTAAGCTACACCCCGATCTGGCTGCTGCTGTTGTCGCTGGTAGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGAGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAATAGCGGTATGCTGCTGCGTTTACGCCATGTCGATACCCGGCGCGG
GCAGCATCTGTGGCTGGCGGCGGATAGCATGGATGCCGGAGAATGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT148050 WP_000138930.1 NZ_CP047811:2662588-2662881 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT148050 NZ_CP063403:774912-775178 [Klebsiella variicola]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References