Detailed information of TA system TA148047

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 1210564..1211093
• Replicon: chromosome
• Accession: NZ_CP047811
• Organism: Staphylococcus aureus strain UP_1522

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: K7ZRX6
• Locus tag: E3T10_RS06150
• Protein ID: WP_001103939.1
• Coordinates: 1210564..1210881 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IY59
• Locus tag: E3T10_RS06155
• Protein ID: WP_001058494.1
• Coordinates: 1210884..1211093 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T10_RS06125	1206570..1207211	-	642	WP_001019808.1	hypothetical protein	-
E3T10_RS06130	1207208..1207492	-	285	WP_000998185.1	hypothetical protein	-
E3T10_RS06135	1207494..1207856	-	363	WP_001039170.1	hypothetical protein	-
E3T10_RS06140	1208157..1209614	-	1458	WP_000390453.1	virulence-associated E family protein	-
E3T10_RS06145	1209631..1210500	-	870	WP_001002717.1	primase alpha helix C-terminal domain-containing protein	-
E3T10_RS06150	1210564..1210881	-	318	WP_001103939.1	DUF1474 family protein	Toxin
E3T10_RS06155	1210884..1211093	-	210	WP_001058494.1	hypothetical protein	Antitoxin
E3T10_RS06160	1211086..1211232	-	147	WP_000784885.1	hypothetical protein	-
E3T10_RS06165	1211244..1211462	-	219	WP_000163544.1	helix-turn-helix domain-containing protein	-
E3T10_RS06170	1211498..1211701	-	204	WP_001045296.1	transcriptional regulator	-
E3T10_RS06175	1211837..1212640	+	804	WP_000358990.1	helix-turn-helix domain-containing protein	-
E3T10_RS06180	1212630..1213736	+	1107	WP_000149511.1	site-specific integrase	-
E3T10_RS06190	1214299..1214763	-	465	WP_001085185.1	SsrA-binding protein SmpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12547.17 Da
• Isoelectric Point: 5.0161

>T148047 WP_001103939.1 NZ_CP047811:c1210881-1210564 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAQKLKITE

Nucleotide

• Length: 318 bp

>T148047 NZ_CP063401:c2034441-2034160 [Devosia sp. SL43]
ATGGAGATCATATGGTCGCCTGAGGCTCAAGGCGAAGTTCAGGCTATCGTCGCCTACATCGCTGACTTTGATCCTGTGGC
CGCGCGGGACATCAGGCTGCGGTTGGAGGCAGTGGTCCTGCCGCTTGCTGAGCATCCATACCTGTTCCGCAGCGGACGGG
TGCTCGGGACGAGAGAGCTTGTCGTGAGTCCCAACTATATTATTGTCTACCGAGTGACGGATCACGTGAGGATCGTTTCG
GTCCTTCATGCCCGGCAGGAATATCCCTCACCGCGCCCGTAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8268.31 Da
• Isoelectric Point: 4.3718

>AT148047 WP_001058494.1 NZ_CP047811:c1211093-1210884 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT148047 NZ_CP063401:c2034637-2034446 [Devosia sp. SL43]
ATGGCCAAGAAGCTCGATCCGATCATTTCGGAATTCGATACGCAGGAACAGGCTGAAAGCTACGATCGCTGGTTCCGGGC
GAAAGTGGAGAAGTCCCTCGCTGATCCACGTCCCGGCATTCCCCATGACCAAGTGATGGCAGAACTCGATGCCATCATCG
CTGCGGCCGAAGCGCGGAAGAAGACCGCCTGA

Structures

Toxin

• AlphaFold DB: K7ZRX6

Antitoxin

• AlphaFold DB: X5IY59