Detailed information of TA system TA148046

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1182493..1182970
• Replicon: chromosome
• Accession: NZ_CP047811
• Organism: Staphylococcus aureus strain UP_1522

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: -
• Locus tag: E3T10_RS05995
• Protein ID: WP_160186312.1
• Coordinates: 1182782..1182970 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: E3T10_RS05990
• Protein ID: WP_001059690.1
• Coordinates: 1182493..1182753 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T10_RS05955	1177886..1178602	-	717	WP_000150033.1	type I 3-dehydroquinate dehydratase	-
E3T10_RS05960	1178750..1179172	+	423	WP_000974451.1	organic hydroperoxide resistance protein	-
E3T10_RS05965	1179571..1180065	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
E3T10_RS05970	1180221..1180838	+	618	WP_000255550.1	LysE/ArgO family amino acid transporter	-
E3T10_RS05975	1180911..1181492	-	582	WP_001140696.1	phosphoglycerate mutase family protein	-
E3T10_RS05980	1181716..1181952	+	237	WP_000368687.1	hypothetical protein	-
E3T10_RS05985	1181949..1182152	-	204	WP_000145160.1	sterile alpha motif-like domain-containing protein	-
E3T10_RS05990	1182493..1182753	+	261	WP_001059690.1	hypothetical protein	Antitoxin
E3T10_RS05995	1182782..1182970	+	189	WP_160186312.1	hypothetical protein	Toxin
E3T10_RS06000	1183158..1183727	+	570	WP_001106662.1	hypothetical protein	-
E3T10_RS06005	1183815..1184087	+	273	WP_001004400.1	hypothetical protein	-
E3T10_RS06010	1184160..1184378	+	219	WP_000005884.1	hypothetical protein	-
E3T10_RS06015	1184875..1185075	-	201	WP_001059082.1	cold-shock protein	-
E3T10_RS06020	1185432..1186118	-	687	WP_001622483.1	thermonuclease family protein	-
E3T10_RS06025	1186459..1186980	-	522	WP_000824479.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Relaxosome protein TraY (4-49)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7172.84 Da
• Isoelectric Point: 9.9971

>T148046 WP_160186312.1 NZ_CP047811:1182782-1182970 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFTILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T148046 NZ_CP063400:5333846-5334115 [Hydrogenophaga sp. SL48]
TTGGCTTGGCAAATTGAGTTCGACCCCGACGCGCTGAAAGAACTCAAAAAACTCGACCGACCGATCCAGACGCGTCTGGT
CGCGTTTCTGCGCGACCGCCTGTCTCTGCTGGAAGACCCACGAAGCATCGGCGAGGCGCTGTCCGGCGCTCGCTTGGGCA
GCTATTGGAAATACCGCGTGGGCGACTGGCGCATCGTTTGCGACATTCAAGACCAGCGCATCGTCGTGCGCGTGTTGCGC
ATCGGCAATCGGCGCGAGGTCTATCGCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT148046 WP_001059690.1 NZ_CP047811:1182493-1182753 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT148046 NZ_CP063400:5333650-5333862 [Hydrogenophaga sp. SL48]
ATGCTAGCCATCCGCCTGACCCCCGACATCGAAGCACGCTTGAACCGCCTGACCCAAGAAACCGGTCGCACCAAGACGGC
CTTGGCGCGCGAGGCCATCTTGGAGCACCTGGACGACCTCGAAGATTTCTACCTGGCTGAAGCCCGGGCGCGAAAAAACC
GCAAGACCATCCCGCTGACCGACGTGGAGCGCGAGCTTGGCTTGGCAAATTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VN56