Detailed information of TA system TA148045

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 119078..119854
• Replicon: chromosome
• Accession: NZ_CP047811
• Organism: Staphylococcus aureus strain UP_1522

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: E3T10_RS00765
• Protein ID: WP_000031109.1
• Coordinates: 119702..119854 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: E3T10_RS00760
• Protein ID: WP_160186290.1
• Coordinates: 119078..119677 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T10_RS00740	114994..116451	+	1458	WP_000649916.1	ABC transporter permease subunit	-
E3T10_RS00745	116444..117166	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
E3T10_RS00750	117317..118444	+	1128	WP_000379990.1	tRNA epoxyqueuosine(34) reductase QueG	-
E3T10_RS00755	118449..118919	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
E3T10_RS00760	119078..119677	+	600	WP_160186290.1	glucosamine-6-phosphate isomerase	Antitoxin
E3T10_RS00765	119702..119854	+	153	WP_000031109.1	hypothetical protein	Toxin
E3T10_RS00770	120681..121076	+	396	WP_000901019.1	hypothetical protein	-
E3T10_RS00775	121272..122657	+	1386	WP_000116239.1	class II fumarate hydratase	-
E3T10_RS00780	123114..123935	-	822	WP_000669377.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5950.31 Da
• Isoelectric Point: 3.9075

>T148045 WP_000031109.1 NZ_CP047811:119702-119854 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Nucleotide

• Length: 153 bp

>T148045 NZ_CP063400:3034179-3034484 [Hydrogenophaga sp. SL48]
ATGAGCACCACCAAGATGAAATCCAAACTGGTCCCGTTCGATGCCGCGCGGTACCTGAGCGACGACACGGCGATTGCCGA
GTACATGAATGCGGTTCTTGAAACCGGCGATACCGATCTGCTGCTGCTCGCACTCGGCGACGTGGCCCGTGCACGCGGTA
TGGCACAAGTGGCAAAGGATGCAGGACTCGGCCGTGAGAGTCTCTACAAGGCGCTGACGCCGGGTGCCAAACCCCGCTTC
GATACCGTGGTCAAGGTGGCTCGGGCGCTGGGGGTTCGGTTGGGTGTGCGGCCTGTTTCTGTGTAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22315.42 Da
• Isoelectric Point: 5.1445

>AT148045 WP_160186290.1 NZ_CP047811:119078-119677 [Staphylococcus aureus]
MAMNFKVFDNSQLAAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT148045 NZ_CP063400:3033880-3034182 [Hydrogenophaga sp. SL48]
GTGTTCACCGTTCTCCAGACTGAAGACTTCCGCGACTGGCTTGATGCCCTCAAGGACATGAAGGCTCAGGTTCGGATCGC
TGCCCGCCTTCGCTTGGCAGAAGCGGGCAGCTTGGGCGACTGGAAGTCGGTGGGCGATGGTTTGTCGGAGATGCGCGTGG
ACGTCGGACCGGGCTACCGCCTCTACTTCACGCGACGACAAAACATCCTCATCGTCATGCTCGCGGGCGGTGACAAGTCA
ACACAGGCCAAGGACATCAAGAGAGCACAAAAGCTCCTGACTCAATTGGAGCTGGAACCATGA