148040

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2838733..2839210 Replicon chromosome
Accession NZ_CP047809
Organism Staphylococcus aureus strain UP_1591

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag E3T14_RS14215 Protein ID WP_000052078.1
Coordinates 2838733..2838921 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3T14_RS14220 Protein ID WP_001059690.1
Coordinates 2838950..2839210 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T14_RS14185 2834774..2835244 + 471 WP_000824472.1 hypothetical protein -
E3T14_RS14190 2835585..2836271 + 687 WP_001548082.1 thermonuclease family protein -
E3T14_RS14195 2836628..2836828 + 201 WP_001059082.1 cold-shock protein -
E3T14_RS14200 2837324..2837542 - 219 WP_000005886.1 hypothetical protein -
E3T14_RS14205 2837604..2837888 - 285 WP_001004395.1 hypothetical protein -
E3T14_RS14210 2837976..2838545 - 570 WP_050956526.1 hypothetical protein -
E3T14_RS14215 2838733..2838921 - 189 WP_000052078.1 hypothetical protein Toxin
E3T14_RS14220 2838950..2839210 - 261 WP_001059690.1 hypothetical protein Antitoxin
E3T14_RS14225 2839551..2839754 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3T14_RS14230 2839751..2839987 - 237 WP_000368687.1 hypothetical protein -
E3T14_RS14235 2840212..2840793 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
E3T14_RS14240 2840866..2841483 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
E3T14_RS14245 2841638..2842132 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3T14_RS14250 2842531..2842953 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
E3T14_RS14255 2843101..2843817 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T148040 WP_000052078.1 NZ_CP047809:c2838921-2838733 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148040 NZ_CP063397:3681281-3681463 [Rhizobium sp. SL42]
ATGGAGACGGATTCACGCAAGATCATCCAGCGTCTCAAGGCCGAGGGCTACGAACTCGTATCGATATCCGGTTCTCATCA
CAAACTCCGCAAGAACGGCAAGAGCGTGATCGTGCCGCACCCGAAGAAACAGCTGCCACTCGGCACCGCGCGCGCAATCG
CCAAACAGGCAGGATGGATCTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148040 WP_001059690.1 NZ_CP047809:c2839210-2838950 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148040 NZ_CP063397:3681484-3681882 [Rhizobium sp. SL42]
ATGAATCACTATGTCGCCATCGTCCACAAGGATGCGGAAAGCGCCTATGGGATCAGCTTTCCGGATCTACCATCCGTGTT
TTCGGCAGCCGACGACGAAGATGACATCGTTGGCAATGCCATCGAAGCCCTGCGCCTCTGGGCTCAAGACGAAAATCTGC
CAGATCCAGCCTCCCACGCGGATATCCTGGCCAGAGAAGATGTGCGCCGTGAACTGAGGGACGGCGCATTTCTGATCCGG
GTGCCTCTGATCGAGGACGACACCAGAACCGTACGCGCCAATATCACGCTGGAGGCAGGAACGCTGGCAGCAATCGATAT
CGCGGCGAAGCAACGCGGATTGACGCGTTCCGCGTTCATCGCGAGTTGCGCCCGAAAGGAAATAGAACGCTCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References