148033

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1271396..1271910 Replicon chromosome
Accession NZ_CP047809
Organism Staphylococcus aureus strain UP_1591

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag E3T14_RS06350 Protein ID WP_000581792.1
Coordinates 1271396..1271605 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag E3T14_RS06355 Protein ID WP_000138932.1
Coordinates 1271617..1271910 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T14_RS06330 1266904..1268262 - 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
E3T14_RS06335 1268277..1269347 - 1071 WP_161575704.1 D-alanine--D-alanine ligase -
E3T14_RS06340 1269665..1270867 + 1203 WP_001109939.1 rod shape-determining protein RodA -
E3T14_RS06345 1271131..1271268 - 138 WP_000828354.1 hypothetical protein -
E3T14_RS06350 1271396..1271605 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
E3T14_RS06355 1271617..1271910 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3T14_RS06360 1272076..1273560 + 1485 WP_000571549.1 cardiolipin synthase -
E3T14_RS06365 1273588..1274235 + 648 WP_001187629.1 HD domain-containing protein -
E3T14_RS06380 1275048..1275920 - 873 WP_000725802.1 membrane protein insertase YidC -
E3T14_RS06385 1276006..1276647 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T148033 WP_000581792.1 NZ_CP047809:c1271605-1271396 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T148033 NZ_CP063397:c1197236-1195974 [Rhizobium sp. SL42]
ATGAGCCGCGTGCTGGACGTCTATCTCAAGGATCGCAAGGCCGGCGAGCTCAAGCAGGACGACGACGCCTCGCTCACCTT
CGCTTATGACGGCGACTACCTCGCCAATGATCCGGTCGCCTTGTCGGTGTCGCTGCCGGTGCAGGAAGAACCCTTCATCG
ATCGCGTCACCCGCCCTTTCTTCTCCGGCCTCCTGCCTGATGAAGGCGCCAGACGCCGATTGGCTGCAGCACTGGGCATA
TCCTCAGGTAACGCCTTCGGGCTGCTCGAGATTATCGGCGGGGAATGTGCGGGCGCCTTATCGCTTGTTCCGCCAGGACA
GCTGCCACCGGCCTCGACTACGGACGATGCCGAGGCGCTGGATGAGAAGCATCTGGAGAAGATCCTCTCCCTGCTCAGAC
AGAGGCCCCTGCTCGGCGGGGAAGCGGACGTGCGCCTTTCGCTTGCCGGCGCTCAGGACAAGCTGGCTGTCACCGTTCTC
AACGGTCAGATATTGCTGCCCCGAGGCGGGCGCCCGACGACGCATATCCTGAAACCGTTCATCGAGGGCCTCGACGGCAC
CGTGGAGAACGAAGTGTTCTGCATGAGCCTGGGACGTCGTCTCGGCCTCGATGTCCCCGCTGTGTCGAAGGGCGCAGCCG
GCAAGGTCGATTACTTCCTGGTCGAGCGCTACGATCGGCTGACGCTTGAAGACGGGCGGATCGAGCGGCTGCACCAGGAA
GACTTCTGCCAGGCGCTGAGCGTGCCCCCGGAGCTCAAATATGAGGAAGAAGGAGGCCCCGGCATCAGTCAGTGCCTCCA
GCTGATCCGGCAGACGACGGCCAAGCCCGCAGCCGAGACATTGCGTTTCCAGCGAATGCTCATGTTTCACTACCTGATCG
GCAATGCCGACGCTCATGCCAAGAACTATGCCCTGCTCTATCGTGGGAAGGCGCCGGACCTGGCACCGATGTATGACGCT
ATTTGCACGGCGGCCTATCCACGACTGTCAAAGAAAATGGCGATGGCACTCGGCGGCAGGTCACTGCCAGATACGATTCA
GATGGAGCACTGGGCGTCGCTCGTGCCGACCAACAAGGCCGCCACGCGCATGCTTGCCGGCGAGCTGGTCCGCATGGCGG
ACACGATCGGGCTGGAAGCCGACGCATTGTTGGAAGAGATGTCCGAGAACGGCACCTACCATCCAATCCTGAAGACCGTC
CGGAAAATCATCGACACCAGATGCGCCCTGGTCAGAAGAGCGCTGGAGAAGCCTAGCCTGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT148033 WP_000138932.1 NZ_CP047809:c1271910-1271617 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT148033 NZ_CP063397:c1197457-1197233 [Rhizobium sp. SL42]
ATGACAACAGTCTCCGATAGCGCAGCACTCGGCCAGCTAATCCGCGCCGAGCGGAAGCGTCAGGAACTTACCCAGGAACA
ACTCGCCGGCGTCGCGGGCGTGGGCGTGAGGTTCGTGCGCGAATTGGAGAGCGGCAAGGAAAGCTGTCGAGTCGGACTTG
CTCTGACCGTCCTGCAGACGCTCGGCTTGACCGTGAGTATTACTTCTCGCGGTGCCTCCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References