Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1200215..1200744 Replicon chromosome
Accession NZ_CP047809
Organism Staphylococcus aureus strain UP_1591

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag E3T14_RS05985 Protein ID WP_001103933.1
Coordinates 1200215..1200532 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag E3T14_RS05990 Protein ID WP_001058487.1
Coordinates 1200535..1200744 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T14_RS05955 1195351..1195692 - 342 WP_000443639.1 hypothetical protein -
E3T14_RS05960 1196228..1196869 - 642 WP_001019811.1 hypothetical protein -
E3T14_RS05965 1196866..1197150 - 285 WP_000998179.1 hypothetical protein -
E3T14_RS05970 1197152..1197514 - 363 WP_153156945.1 pathogenicity island protein -
E3T14_RS05975 1197793..1199262 - 1470 WP_094754105.1 virulence-associated E family protein -
E3T14_RS05980 1199279..1200148 - 870 WP_161575700.1 primase alpha helix C-terminal domain-containing protein -
E3T14_RS05985 1200215..1200532 - 318 WP_001103933.1 DUF1474 family protein Toxin
E3T14_RS05990 1200535..1200744 - 210 WP_001058487.1 hypothetical protein Antitoxin
E3T14_RS05995 1200737..1200883 - 147 WP_000708434.1 hypothetical protein -
E3T14_RS06000 1200880..1201197 - 318 WP_072532959.1 helix-turn-helix domain-containing protein -
E3T14_RS06005 1201202..1201420 - 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
E3T14_RS06010 1201593..1202267 + 675 WP_000620857.1 helix-turn-helix transcriptional regulator -
E3T14_RS06015 1202281..1203453 + 1173 WP_000179346.1 site-specific integrase -
E3T14_RS06020 1203522..1205138 - 1617 WP_000240645.1 chaperonin GroEL -
E3T14_RS06025 1205214..1205498 - 285 WP_000917289.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 1184339..1205498 21159


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T148031 WP_001103933.1 NZ_CP047809:c1200532-1200215 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T148031 NZ_CP063396:c5337333-5336923 [Pseudomonas aeruginosa]
ATGCTCAAGTTCATGCTTGACACCAACATCTGCATCTTCACTATCAAGAACCGCCCGCAAGAGGTGCGCGAGGCGTTCCT
GCGCCACCACGACCAGATGTGCATCAGCACCGTGACGCTGATGGAGCTGATCTACGGCGCAGAGAAGTCCTCGAACCCCT
CGCGCAATCTTGCAGACGTGGAAGGCTTCGCTGCTCGTCTGGAGGTGCTCAAGTACGACCAGGAAGCTGCCGCCCACACC
GGCCAGCTCCGCGCTGAACTGGCCCGCCTCGGCAAGCAAATCGGCCCCTATGACCAGATGATCGCCGGACACGCCCGCTC
TCAGGGCCTGATCGTGGTCACCAATAACCGCCGCGAGTTCGACCGCGTACCCGGCTTGAGAGTTGAGGATTGGGTCACCC
CAATCGTATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT148031 WP_001058487.1 NZ_CP047809:c1200744-1200535 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT148031 NZ_CP063396:c5337563-5337333 [Pseudomonas aeruginosa]
GTGGAACAAGGTTCTGTTTTTCAGAGCAATCGTAGCCAGGCCGTAAGACTGCCCAAGGCCGTCGCGCTTCCTGATGACGT
TAAGCGTGTGGATGTGGTCGCTGTGGGGCGCGCCAGAATCATCACGCCTGCCGGCGAGTCTTGGGATAGTTGGTTCGATG
GCGAGGGCGTTACTGCCGACTTTATGGCAGAGCGTGAACAGCCTGCCGATCAGGAGCGCGAGACTTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References