Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1134260..1134737 Replicon chromosome
Accession NZ_CP047807
Organism Staphylococcus aureus strain UP_1612

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3T15_RS05695 Protein ID WP_000052076.1
Coordinates 1134549..1134737 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3T15_RS05690 Protein ID WP_001059690.1
Coordinates 1134260..1134520 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T15_RS05655 1129652..1130368 - 717 WP_000150016.1 type I 3-dehydroquinate dehydratase -
E3T15_RS05660 1130516..1130938 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
E3T15_RS05665 1131337..1131831 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3T15_RS05670 1131987..1132604 + 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
E3T15_RS05675 1132677..1133258 - 582 WP_001140697.1 phosphoglycerate mutase family protein -
E3T15_RS05680 1133483..1133719 + 237 WP_000368687.1 hypothetical protein -
E3T15_RS05685 1133716..1133919 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3T15_RS05690 1134260..1134520 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3T15_RS05695 1134549..1134737 + 189 WP_000052076.1 hypothetical protein Toxin
E3T15_RS05700 1134925..1135494 + 570 WP_001106652.1 hypothetical protein -
E3T15_RS05705 1135582..1135866 + 285 WP_001004401.1 hypothetical protein -
E3T15_RS05710 1135928..1136146 + 219 WP_000005887.1 hypothetical protein -
E3T15_RS05715 1136642..1136842 - 201 WP_001059082.1 cold-shock protein -
E3T15_RS05720 1137199..1137885 - 687 WP_160179415.1 thermonuclease family protein -
E3T15_RS05725 1138226..1138702 - 477 WP_000824477.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T148014 WP_000052076.1 NZ_CP047807:1134549-1134737 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T148014 NZ_CP063393:c5603387-5603109 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT148014 WP_001059690.1 NZ_CP047807:1134260-1134520 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT148014 NZ_CP063393:c5603097-5602792 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References