Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1240829..1241306 Replicon chromosome
Accession NZ_CP047805
Organism Staphylococcus aureus strain UP_1654

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E3T17_RS06235 Protein ID WP_000052076.1
Coordinates 1241118..1241306 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E3T17_RS06230 Protein ID WP_001059690.1
Coordinates 1240829..1241089 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T17_RS06195 1236221..1236937 - 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -
E3T17_RS06200 1237085..1237507 + 423 WP_160325475.1 organic hydroperoxide resistance protein -
E3T17_RS06205 1237906..1238400 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
E3T17_RS06210 1238556..1239173 + 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
E3T17_RS06215 1239246..1239827 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
E3T17_RS06220 1240052..1240288 + 237 WP_000368687.1 hypothetical protein -
E3T17_RS06225 1240285..1240488 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E3T17_RS06230 1240829..1241089 + 261 WP_001059690.1 hypothetical protein Antitoxin
E3T17_RS06235 1241118..1241306 + 189 WP_000052076.1 hypothetical protein Toxin
E3T17_RS06240 1241494..1242063 + 570 WP_001106663.1 hypothetical protein -
E3T17_RS06245 1242151..1242435 + 285 WP_001004401.1 hypothetical protein -
E3T17_RS06250 1242497..1242715 + 219 WP_000005879.1 hypothetical protein -
E3T17_RS06255 1243212..1243412 - 201 WP_001059082.1 cold-shock protein -
E3T17_RS06260 1243769..1244455 - 687 WP_001574556.1 thermonuclease family protein -
E3T17_RS06265 1244796..1245353 - 558 WP_000824491.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T147997 WP_000052076.1 NZ_CP047805:1241118-1241306 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T147997 NZ_CP063391:c144713-144432 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT147997 WP_001059690.1 NZ_CP047805:1240829-1241089 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT147997 NZ_CP063391:c144937-144710 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References